KHẢO SÁT MỐI LIÊN QUAN GIỮA CÁC CHỈ SỐ CÔNG THỨC MÁU VÀ CÁC TỈ SỐ VIÊM DẪN XUẤT (NLR, PLR, SII) VỚI MỨC LỌC CẦU THẬN ƯỚC TÍNH VÀ NỒNG ĐỘ ACID URIC MÁU Ở BỆNH NHÂN BỆNH THẬN ĐÁI THÁO ĐƯỜNG

Abstract

Objective: To investigate the association between complete blood count (CBC) parameters and derived inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), with estimated glomerular filtration rate (eGFR) and serum uric acid levels in patients with diabetes mellitus and diabetic kidney disease. Methods: A cross-sectional study was conducted on 437 patients with diabetes mellitus treated at Xanh Pôn General Hospital. Diabetic kidney disease was defined as urine albumin-to-creatinine ratio ≥30 mg/g and/or eGFR <60 mL/min/1.73 m². Associations between CBC parameters, inflammatory indices, eGFR, and serum uric acid were analyzed using correlation analysis and univariate logistic regression. Discriminative ability was assessed using receiver operating characteristic (ROC) curves. Results: Total white blood cell count and SII were significantly negatively correlated with eGFR. Serum uric acid was negatively correlated with eGFR and positively correlated with white blood cell count. ROC analysis showed that white blood cell count, NLR, and SII had moderate ability to discriminate reduced eGFR. Conclusion: CBC-derived inflammatory indices, particularly white blood cell count and SII, are associated with impaired renal function and may support screening for diabetic kidney disease.