ĐÁNH GIÁ BƯỚC ĐẦU KẾT QUẢ ĐIỀU TRỊ THOÁI HÓA KHỚP GỐI BẰNG PHƯƠNG PHÁP TIÊM NỘI KHỚP HUYẾT TƯƠNG GIÀU TIỂU CẦU KẾT HỢP FIBRIN GIÀU TIỂU CẦU

Abstract

Background and Objectives: Knee osteoarthritis (OA) is a common degenerative disease that causes chronic pain and functional limitation, while current therapies remain suboptimal. Platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) are autologous biologic approaches with potential regenerative effects. This study aimed to preliminarily evaluate the safety and efficacy of intra-articular PRP combined with PRF in knee OA at the 175 Military Hospital. Methods: A prospective, single-arm, open-label study was conducted on 20 patients (37 knees) with stage II–IV OA from January 2024 to January 2025. All patients received intra-articular injections of PRP plus PRF once weekly for three weeks. Clinical outcomes (VAS, WOMAC) and ultrasound parameters (joint effusion, synovitis) were assessed at 7 days, 15 days, 1 month, and 3 months after treatment. Results: No serious adverse events were reported. At 3 months, mean VAS score decreased from 6.27 ± 0.73 to 2.14 ± 0.79; joint effusion reduced from 100% to 43.24%; and synovitis decreased from 18.92% to 0%. WOMAC scores showed significant improvement compared with baseline (p < 0.05). Mild post-injection pain was observed in some patients but resolved spontaneously within hours. Conclusion: Intra-articular injection of PRP combined with PRF following a 3-week protocol is safe and provides significant short-term improvements in pain, joint function, and ultrasound findings in patients with knee OA. These findings suggest PRP–PRF therapy as a promising, biologically based option for clinical management of knee osteoarthritis.