BISPHOSPHONATE-RELATED OSTEONECROSIS OF THE JAW: A TWO-CASE REPORT
Main Article Content
Abstract
Osteonecrosis of the jaw is a complication of osteoporosis treatment by bisphosphonate, which can cause serious issues for patients. This is a rare complication with unspecific symptoms and signs, and so makes it difficult to diagnose at early stage. Thus, leads to severe jaw destruction and needs to operate. In Hanoi Medical University hospital, we had two patients who diagnosed with oral bisphosphonate-related osteonecrosis of the jaw. Both patients were under operation to remove death bone and brought good results.
Article Details
Keywords
osteonecrosis of the jaw, bisphosphonate, osteoporosis
References
2. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. Journal of Oral and Maxillofacial Surgery. 2003;61(9):1115-1117. doi:10.1016/S0278-2391(03)00720-1
3. Khan AA, Morrison A, Hanley DA, et al. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015;30(1):3-23. doi:10.1002/jbmr.2405
4. Cosman F, de Beur SJ, LeBoff MS, et al. Clinician’s Guide to Prevention and Treatment of Osteoporosis. Osteoporos Int. 2014;25(10):2359-2381. doi:10.1007/s00198-014-2794-2
5. Abe T, Sato T, Kokabu S, et al. Zoledronic acid increases the circulating soluble RANKL level in mice, with a further increase in lymphocyte-derived soluble RANKL in zoledronic acid- and glucocorticoid-treated mice stimulated with bacterial lipopolysaccharide. Cytokine. 2016;83:1-7. doi:10.1016/j.cyto.2016.03.012
6. Yamazaki T, Yamori M, Yamamoto K, et al. Risk of osteomyelitis of the jaw induced by oral bisphosphonates in patients taking medications for osteoporosis: A hospital-based cohort study in Japan. Bone. 2012;51(5):882-887. doi:10.1016/j.bone.2012.08.115
7. Ruggiero SL, Dodson TB, Fantasia J, et al. American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw—2014 Update. Journal of Oral and Maxillofacial Surgery. 2014;72(10):1938-1956. doi:10.1016/j.joms.2014.04.031
8. Hellstein JW, Adler RA. Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis. Recommendations from the American Dental Association Council on Scientific Affairs.2011.
9. Adler RA, El-Hajj Fuleihan G, Bauer DC, et al. Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2016;31(1):16-35. doi:10.1002/jbmr.2708