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Date Published: 05/05/2021
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DOI: https://doi.org/10.51298/vmj.v498i2.182
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Vol. 498 No. 2 (2021)
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Các bài báo
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Đức Hoàng Đồng, & Xuân Quýnh, N. (2021). CARBOHYDRATE ANTIGEN 19-9 (CA 19-9) AND CARCINOEMBRYONIC ANTIGEN (CEA) SERUM MARKERS ARE ASSOCIATED WITH SOME FACTORS OF CHOLANGIOCARCINOMA. Vietnam Medical Journal, 498(2). https://doi.org/10.51298/vmj.v498i2.182

CARBOHYDRATE ANTIGEN 19-9 (CA 19-9) AND CARCINOEMBRYONIC ANTIGEN (CEA) SERUM MARKERS ARE ASSOCIATED WITH SOME FACTORS OF CHOLANGIOCARCINOMA

Đồng Đức Hoàng, Nguyễn Xuân Quýnh

Main Article Content

Abstract

Background: Cholangiocarcinoma (CCA) is a primary malignant tumor that originates in bile duct epithelial cells. The disease is often detected at late stage and the bad prognosis of this tumor leads to an urgent need to learn about biomarkers. Aim: to evaluate the relationship between serum CEA, CA 19-9 levels and factors in CCA patients. Methods: A prospective study was carried out in 52 CCA patients. Patients were immunized Carbohydrate antigen 19-9 (CA 19-9), Carcinoembryonic antigen (CEA); abdominal CT scan, endoscopy, bone scintigraphy to assess metastases. Diagnosis of CCA was determined by biopsy and histopathological examination by Hematoxylin-Eosin staining method. Results: The rate of increase in CA 19-9 was 63.5%. The CEA increase rate was 44.2%. CA 19-9 was highest (756.2 ± 871.3) in TNM stage 3, p = 0.9. The highest CEA (184.6 ± 371.2) in TNM stage 3, p = 0.3. Mean CA 19-9 of intra hepatic CCAwas 715.3 ± 605.7, extra hepatic CCA 436.2 ± 517.5, p = 0.2. The mean CEA of intra hepatic CCAwas 88.0 ± 268.9, extra hepatic CCA 17.6 ± 23.4, p = 0.4. CA 19-9 serum level and tumor size had a weak linear correlation, r = 0.22 (r <0.3), p = 0.11. CEA serum level and tumor size had a weak linear correlation, r = 0.19 (r <0.3), p = 0.17. Mean CA 19-9 of resectable patients was 278.4 ± 522.6, much lower than that of unresectable patients 756.8 ± 582.4, p = 0.02. Mean CEA of resectable patients was 49.8 ± 122.1, lower than that of unresectable patients 82.6 ± 268.0, p = 0.7. Conclusion: CA 19-9 levels in resectable patients were lower than patients treated with chemotherapy, radiation and palliative care. No association between CEA and TNM stage, biliary cancer classification, indications for treatment.

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Keywords

Cholangiocarcinoma, Carbohydrate antigen 19-9, Carcinoembryonic antigen

References

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