RISK FACTORS FOR URINARY TRACT INFECTION AND PREDICTIVE VALUE OF HEMATOLOGIC INFLAMMATORY MARKERS IN PATIENTS WITH STONES

Thị Hồng Thơm Trần 1, Thị Thu Hương Trần1,2,, Minh Thụy Đoàn 1, Hoàng Hòa Nguyễn 2, Trung Kiên Ngô2
1 Vietnam University of Traditional Medicine
2 Saint Paul Hospital

Main Article Content

Abstract

Objective: To identify risk factors for urinary tract infection (UTI) and to evaluate the predictive value of NLR và SII in patients with kidney stones. Methods: A cross-sectional descriptive study was conducted on 315 patients aged ≥18 years who were diagnosed with kidney stones at Saint Paul Hospital from July to October 2025. UTI was defined based on clinical symptoms, complete blood count, and urinalysis findings. Clinical, metabolic, renal function, imaging characteristics, and inflammatory markers (WBC, NLR, MLR, SII) were collected prior to intervention. Receiver operating characteristic (ROC) analysis was used to assess the predictive value of NLR and SII. Results: The prevalence of UTI was 48.6%. Type 2 diabetes mellitus, decreased glomerular filtration rate, stone size >10 mm, and hydronephrosis ≥ grade 2 were significantly associated with UTI. NLR and SII demonstrated acceptable sensitivity and specificity in predicting UTI and risk stratification before intervention. Conclusion: UTI is a common complication in patients with kidney stones. Diabetes mellitus, impaired renal function, and imaging characteristics increase the risk of infection. NLR and SII may serve as useful tools for pre-intervention risk stratification.

Article Details

References

1. Hội tiết niệu và thận học Việt Nam (VUNA-2020). Hướng dẫn điều trị nhiễm khuẩn đường tiết niệu. Một số nhiễm khuẩn đường tiết niệu phức tạp thường gặp: Nhiễm khuẩn đường tiết niệu liên quan tới sỏi - đái tháo đường - bệnh thận mạn. Bản cập nhật 2020. Nhà xuất bản Đại học Huế. Tr 82-84.
2. Liu H, Guo M, Jia H, et al (2024). Association between cardiometabolic index and kidney stones in US diabetic patients: NHANES 2007-2018. World J Urol, Nov 28;42(1):653.
3. Parks JH, Coe FL. The increasing number of calcium oxalate stone cases exacerbates treatment outcomes. Kidney Int 1994;45:1722-30.
4. Mao W, Wu J, Chen M (2021). Neutrophil-lymphocyte ratio acts as a novel diagnostic biomarker for kidney stone prevalence and number of stones passed. Transl Androl Urol. Jan;10(1):77-86.
5. Zhou Q, Shao X, Chen W, et al (2024). Association between Monocyte-to-Lymphocyte Ratio and Inflammation in Chronic Kidney Disease: A Cross-Sectional Study. Kidney Blood Press Res ;49(1):1066-1074.
6. Xiaomin Yang, Chunyan Lang (2024). Analysis of Risk Factors for Urosepsis in Patients with Type 2 Diabetes Complicated by Upper Urinary Tract Stones: A Single-Centre Retrospective Study. Arch Esp Urol. 2024 Sep;77(8):875-881
7. Lê Thị Phương, Đặng Thị Việt Hà, Đỗ Gia Tuyển, Nghiêm Trung Dũng, Tống Thị Thu Hằng (2023). Khảo sát thực trạng nhiễm khuẩn tiết niệu ở bệnh nhân có can thiệp đường tiết niệu. Tạp chí Y học Việt Nam Tập 532- Số 1B ; 338-342.