MICROBIOLOGICAL CHARACTERISTICS AND ANTIMICROBIAL RESISTANCE OF BILE AND BLOOD ISOLATES IN ACUTE CHOLANGITIS PATIENTS
Main Article Content
Abstract
Background: Acute cholangitis is a medical emergency with high mortality rates due to sepsis and septic shock. Furthermore, the evolving microbial profile and rising antibiotic resistance pose significant therapeutic challenges.
Objective: To analyze the microbiology and antimicrobial resistance of bile and blood bacterial isolates in patients with acute cholangitis.
Methods: A retrospective analysis was conducted on 270 acute cholangitis patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) at 108 Military Central Hospital from February 2021 to December 2025.
Results: Bile culture positivity significantly exceeded blood culture (83.6% vs. 62.8%, p < 0.001), with 37.2% showing isolated bile positivity.”E. coli, K.pneumoniae, and P.aeruginosa were identified as the predominant pathogens. Susceptibility rates to Amikacin and Ertapenem exceeded >90% for isolates from both bile and blood sources, showing no statistically significant difference (p > 0.05) whereas high resistance was observed for Ciprofloxacin and third-generation cephalosporins.
Conclusion: The combination of bile and blood cultures optimize pathogen indentification. E.coli, K.pneumoniae and P.aeruginosa remain the primary etiologic agents, exhibiting high sensitivity to Amikacin and Ertapenem.
Keywords
Acute cholangitis, Bile bacterial culture, antibiotics
Article Details
References
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