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Date Published: 13/01/2022
Abstract Views: 278
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DOI: https://doi.org/10.51298/vmj.v509i2.1862
Issue
Vol. 509 No. 2 (2021)
Section
Các bài báo
How to Cite
Văn Hiệp, C. ., Xuân Tĩnh, Đỗ ., Văn Linh, N. ., Việt Hùng, Đinh ., & Thị Thu, P. . (2022). CORRELATION BETWEEN PLASMA CONCENTRATIONS OF DOPAMINE AND SOME CLINICAL PARAMETERS IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER. Vietnam Medical Journal, 509(2). https://doi.org/10.51298/vmj.v509i2.1862

CORRELATION BETWEEN PLASMA CONCENTRATIONS OF DOPAMINE AND SOME CLINICAL PARAMETERS IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER

Cao Văn Hiệp1,, Đỗ Xuân Tĩnh1, Nguyễn Văn Linh1, Đinh Việt Hùng1, Phạm Thị Thu1
1 Military Hospital 103

Main Article Content

Abstract

Objective: To investigate the correlation between plasma concentrations of Dopamine and some clinical parameters in patients with major depressive disorder. Subjects and Methods: Descriptive cross-sectional study in a patient group of 62 inpatients with major depression treated at the Department of Psychiatry, Military Hospital 103. A control group consisted of 31 healthy participants whose sex and age were similar to the group of patients. Results: The proportion of male subjects was higher than that of female ones, but the difference was not statistically significant. The mean ages in the patients and the controls were 38.76±13.20 and 39.71±14.27, respectively; the gap was still insignificant, with p>0.05. The mean concentrations of Plasma Dopamine in the group of patients was (24.96±12.55 pg/ml) lower than the figure for the group of controls (28.72±11.95 pg/ml); However, the disparity was not statistically considerable, with p>0.05. Dopamine levels in plasma in the subjects (both the patient group and the control group) insignificantly differed by sex and age. The depressed patients with psychotic features had lower levels of plasma Dopamine than the patients without psychosis; the difference was not statistically significant (18.26±13.32 pg/ml and 25.68±12.38 pg/ml, with p>0.05). There was no correlation between plasma concentrations of Dopamine and Beck depression inventory scores. Conclusion: The study showed the concentrations of Plasma Dopamine in depressed patients changed insignificantly to the figures for the controls. Furthermore, the Dopamine levels in plasma in the depressed patients did not depend on sex, age, psychotic features, and Beck depression inventory scores.

Article Details

Keywords

plasma concentrations of Dopamine, major depressive disorder

References

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