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Date Published: 13/01/2022
Abstract Views: 367
Views PDF: 196
DOI: https://doi.org/10.51298/vmj.v509i2.1866
Issue
Vol. 509 No. 2 (2021)
Section
Các bài báo
How to Cite
Thị Bích Phượng, L. ., Quyết, Đỗ ., Văn Đông, L., Văn Mão, C., Lĩnh Toàn, N. ., Viết Nhung, N. ., Khắc Hưng, Đồng ., & Minh Trung, Đỗ . (2022). THE CHANGES OF CYTOKINE LEVEL IN THE BLOOD OF COPD PATIENTS AFTER ALLOGENEIC UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELL TRANSPLANTATION WITH PLALETE RICH PLASMA. Vietnam Medical Journal, 509(2). https://doi.org/10.51298/vmj.v509i2.1866

THE CHANGES OF CYTOKINE LEVEL IN THE BLOOD OF COPD PATIENTS AFTER ALLOGENEIC UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELL TRANSPLANTATION WITH PLALETE RICH PLASMA

Lê Thị Bích Phượng1,, Đỗ Quyết2, Lê Văn Đông3, Cấn Văn Mão4, Nguyễn Lĩnh Toàn4, Nguyễn Viết Nhung5, Đồng Khắc Hưng2, Đỗ Minh Trung2
1 Van Hanh General Hospital
2 Institute of BioMedicine and Pharmacy, Vietnam Military Medical University
3 Military Institute of Preventive Medicine
4 Vietnam Military Medical University
5 National Lung Hospital

Main Article Content

Abstract

Objective: To study the changes of cytokine level in the blood of COPD patients after allogeneic umbilical cord-derived mesenchymal stem cell (UC-MSC) transplantation with platelets rich protein. Subjects and methods: Plasma of 10 COPD patients treated by internal medicine and 18 ones by UC-MSC transtplantation were collected at the National Lung Hospital and Van Hanh Hospital at the time points before transplantation (0) and after 1, 3, 7 and 12 months of transplantation. The quantitative concentrations of cytokines were measured by ELISA. Results: Before the treatment, the cytokine levels of the control group were not significantly higher than that of the treated group (p>0,05). After the treatment, in the control group, IL-8, IL-1β, IL-6, IFN-γ and IL-10 levels tended to increase, while TNF-α and VEGF decreased (p>0,05). In contrast, the cytokine levels of the treated group decreased; IL-10 and VEGF expression increased (p<0,05). Conclusion: The inflammatory cytokine levels of UC-MSC transplantation with platelets rich protein patients decreased and VEGF increased after treatment, which may limit the inflammation and enhanced the tissue regeneration.

Article Details

Keywords

COPD, Mesenchymal stem cell, Interleukin

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