CLINICAL, PARACLINICAL CHARACTERISTICS AND TREATMENT OUTCOMES OF NEONATES BORN TO DIABETIC MOTHERS AT THE PEDIATRIC CENTER OF BACH MAI HOSPITAL IN 2023

Mạnh Cường Đỗ 1, Văn Đếm Phạm 1,2, Tiến Đạt Trần 1,
1 University of Medicine and Pharmacy, Vietnam National University, Hanoi
2 Bach Mai Hospital

Main Article Content

Abstract

Objective: To describe the clinical and paraclinical characteristics and treatment outcomes of neonates born to diabetic mothers at the Pediatrics Center of Bach Mai Hospital in 2023.


Methods: A cross-sectional descriptive study with a control group was conducted on 200 neonates, including 100 infants of diabetic mothers (IDM group) and 100 infants of non-diabetic mothers (control group) at the Pediatrics Center, Bach Mai Hospital, in 2023.


Results: In the IDM group, gestational diabetes mellitus (GDM) accounted for 85%, followed by Type 1 DM (8%) and Type 2 DM (7%). The mean maternal age was 32.38 ± 5.35 years, with a significantly increased risk of DM in mothers aged ≥30. Infants born to diabetic mothers had a 4.73-fold higher risk of preterm birth (64%) and a 3.36-fold higher risk of macrosomia (17%). The Cesarean section rate in the IDM group was 94%. Prevalent acute complications included: neonatal respiratory distress syndrome (25%), neonatal hypoglycemia (26%) and neonatal jaundice (52%). Regarding management, 33% of the infants required respiratory support and 22% required acute treatment for hypoglycemia.


Conclusion: Neonates born to diabetic mothers are at significantly high risk for acute neonatal complications. Effective screening, optimal glycemic control during pregnancy, multidisciplinary coordination between Obstetrics and Pediatrics are key factors in managing and improving neonatal outcomes.

Article Details

References

1. Ogurtsova K., Da Rocha Fernandes J.D., Huang Y., et al. (2017). IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Research and Clinical Practice, 128, 40-50.
2. Charles F.P. (2023). Infant of Diabetic Mother: Overview, Complications, Workup.
3. WHO (2013), Tiêu chuẩn chẩn đoán và phân loại tăng đường huyết được phát hiện lần đầu tiên trong thai kỳ.
4. Battarbee A.N., Venkatesh K.K., Aliaga S., et al. (2020). The association of pregestational and gestational diabetes with severe neonatal morbidity and mortality. J Perinatol, 40(2), 232-239.Fay E., Simmons L., and Brown C. (2024). Maternal Diabetes. Avery’s Diseases of the Newborn (Eleventh Edition), 67-81.
5. Kawakita T. et al (2017), "Increased Neonatal Respiratory Morbidity Associated with Gestational and Pregestational Diabetes", Am J Perinatol, 34(11), 1160-1168.
6. Crowther Caroline A., Hiller Janet E., Moss John R., et al. (2005). Effect of Treatment of Gestational Diabetes Mellitus on Pregnancy Outcomes. New England Journal of Medicine, 352(24), 2477-2486.
7. Yamamoto J.M., Donovan L.E., Mohammad K., et al. (2020). Severe neonatal hypoglycaemia and intrapartum glycaemic control in pregnancies complicated by type 1, type 2 and gestational diabetes. Diabetic Medicine, 37(1), 138-146.
8. Rafiq W., Hussain S.Q., Jan M., et al. (2015). Clinical and metabolic profile of neonates of diabetic mothers. International Journal of Contemporary Pediatrics, 2(2), 114-118.