PREGNANCY OUTCOMES IN PATIENTS WITH AND WITHOUT CHR ONICENDOMETRITIS UNDERGOING IN VITRO FERTILIZATION AT HAI PHONG OBSTETRICS AND GYNECOLOGY HOSPITAL
Main Article Content
Abstract
Objective: To determine the prevalence of chronic endometritis (CE) and evaluate pregnancy outcomes in patients with and without this condition undergoing in vitro fertilization (IVF).
Subjects and Methods: A prospective cohort study was conducted on 103 patients undergoing IVF at Hai Phong Obstetrics and Gynecology Hospital from August 2024 to August 2025. CE was diagnosed based on CD138 immunohistochemical staining (≥5 plasma cells per 10 high-power fields). Patients were divided into CE and non-CE groups. The CE group received antibiotic treatment prior to embryo transfer. Pregnancy outcomes were compared between the two groups.
Results: The prevalence of CE was 37.9% (39/103). There was no statistically significant difference between the two groups regarding IVF cycle characteristics and embryo transfer characteristics (p > 0.05). The pregnancy rate in the treated CE group was higher than in the non-CE group (71.1% vs. 55.7%), although the difference was not statistically significant (p > 0.05). Clinical pregnancy and ongoing pregnancy rates in the treated CE group were 68.4% and 60.5%, respectively, significantly higher than those in the non-CE group (47.5% and 39.3%) with p = 0.04. Subgroup analysis showed that patients with mild CE (5 ≤ CD138 < 10) had the highest pregnancy outcomes.
Conclusion: Chronic endometritis is relatively prevalent among infertile patients undergoing IVF. Screening and treatment prior to embryo transfer may improve IVF outcomes, particularly clinical and ongoing pregnancy rates.
Keywords
Chronic endometritis, CD138, in vitro fertilization
Article Details
References
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