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Issue: Vol. 562 No. 2 (2026)
Section: Các bài báo
DOI: 10.51298/vmj.v562i2.18855
Date Published: 06/09/2026
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Downloads 32
How to Cite
Lê , B. H., Nguyễn , Đ. C., & Hoàng , V. S. (2026). ANTIBIOTIC RESISTANCE PATTERNS OF KLEBSIELLA PNEUMONIAE IN ELDERLY PATIENTS WITH PNEUMONIA AT THONG NHAT HOSPITAL. Vietnam Medical Journal, 562(2). https://doi.org/10.51298/vmj.v562i2.18855

ANTIBIOTIC RESISTANCE PATTERNS OF KLEBSIELLA PNEUMONIAE IN ELDERLY PATIENTS WITH PNEUMONIA AT THONG NHAT HOSPITAL

Bảo Huy Lê 1,2, , Đức Công Nguyễn 2,3, Văn Sỹ Hoàng 1
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 Thong Nhat Hospital, Ho Chi Minh City
3 Pham Ngoc Thach University of Medicine, Ho Chi Minh City

Main Article Content

Abstract

Objective: To analyze the epidemiological characteristics and evaluate the antibiotic resistance levels of Klebsiella pneumoniae strains causing pneumonia in the elderly. Methods: A prospective, cross-sectional descriptive study was conducted on 293 inpatients aged ≥ 60 years treated for K. pneumoniae pneumonia at Thong Nhat Hospital from January 2023 to October 2024. Results: The median age was 81 years, with 67.2% being male. The prevalence of multidrug-resistant (MDR) strains was 38.6%, significantly higher in hospital-acquired pneumonia (HAP) at 58.0% compared to community-acquired pneumonia (CAP) at 26.5% (p < 0.05). Carbapenem-resistant K. pneumoniae (CRKP) accounted for 29.7%. Infections with MDR and CRKP strains elevated mortality risk by 2.74 and 2.95 times, respectively. The bacteria exhibited >50% resistance to most beta-lactams and quinolones but remained highly susceptible to Amikacin (1.5% resistance) and Colistin (10.0% resistance). Conclusion: K. pneumoniae in elderly patients exhibits alarmingly high multidrug resistance, particularly in hospital settings. Amikacin and Colistin remain among the few effective therapeutic options.

Keywords

Klebsiella pneumoniae, antibiotic resistance, elderly, pneumonia

Article Details

References

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