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Date Published: 25/02/2022
Abstract Views: 315
Views PDF: 197
DOI: https://doi.org/10.51298/vmj.v510i1.1890
Issue
Vol. 510 No. 1 (2022)
Section
Các bài báo
How to Cite
Văn An, H. ., Mạnh An, H. ., & Anh Tuấn, N. . (2022). THE RESULTS OF PREOPERATIVE CHEMO-RADIOTHERAPY TREATMENT FOR STAGE III RECTAL CANCER . Vietnam Medical Journal, 510(1). https://doi.org/10.51298/vmj.v510i1.1890

THE RESULTS OF PREOPERATIVE CHEMO-RADIOTHERAPY TREATMENT FOR STAGE III RECTAL CANCER

Hoàng Văn An1,, Hoàng Mạnh An1, Nguyễn Anh Tuấn2
1 Military Hospital 103
2 108 Military Central Hospital

Main Article Content

Abstract

Objectives: To evaluate the results of surgery treatment for stage III rectal cancer with preoperative chemo-radiotherapy with Cappecitabine at Central Military Hospital 108. Subjects and methods: Progressive and retrospective descriptive research on 73 patients with rectal cancer Stage III from December 2015 to March 2019 who have received preoperative chemoradiotherapy with 50.4Gy/Fx dose in 5.5 weeks with Capecitabine 825mg/m2, twice a day x 5-7 days/week and surgery. All of the patients underwent surgery after 4 to 12 weeks since finishing chemoradiotherapy. Evaluate the toxicity of chemoradiotherapy, clinical response, postoperative pathological anatomy response, sphincter preservation and postoperative complications. Results: Rate of clinical complete response is 75,3% (55/73), including 8.2% (6/73) of comprehensive response. In terms of postoperative anatomy, rate of patients with tumor (T) period reduction response is 54.79% (40/73), including 4.1% (3/73) of comprehensive response (pT0). All patients tolerated treatment well, no toxicity at level 4. Rectal inflammation caused by radiation at level 1-2 accounts for 27.4% (20/73) and at level 3 accounts for 1.3% with 1 case, dermatitis due to radiation at level 1- 2 accounts for 30.1% (22/73) , fatigue at level 1-2 accounts for 17.8% (13/73), urinary tract inflammation at level 1 accounts for 8.2% (6/73), weight loss  accounts for 9.6% (7/73). Anal sphincter conservation surgery reaches 84.9% (62/73). Postoperative complications account for only 6.8% (5/73) of leakage. Conclusion: Stage III rectal cancer treatment results by preoperative chemo-radiotherapy with Capecitabine have achieved high rate of post-operative period reduction and increase the capability of anal sphincter conservation surgery.

Article Details

Keywords

Preoperative chemo-radiotherapy, rectal cancer

References

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