KHẢO SÁT GIÁ TRỊ ALPHA-FETOPROTEIN HUYẾT THANH Ở BỆNH NHÂN XƠ GAN CÓ UNG THƯ BIỂU MÔ TẾ BÀO GAN

Abstract

Objective: To investigate alpha-fetoprotein (AFP) level in cirrhotic patients with and without hepatocellular carcinoma (HCC). Method: A cross-sectional study describing 75 cases of patients with cirrhosis was conducted at the University Medical Center. We recorded 46 cases of HCC and 29 cases without HCC from September 2020 to January 2021. Results: The mean age of patients was 61,9 ± 10,9, the ratio male/female was 1,68/1. The AUROC of AFP levels for the diagnosis of HCC in cirrhotic patients was 0,8291 (p <0.05), AFP cut-off threshold ≥ 10,9 ng / ml was highest for diagnosing HCC in cirrhotic patients with the sensitivity of 80,43% and the specificity 75,86%. Conclusion: Serum AFP level is a simple test of high sensitivity and specificity in screening for HCC complications in cirrhotic patients.