PREPARATION OF HERBAL CAPSULE CONTAINING ELSHOLTZIA CILIATA (THUNB) HYLAND

Nguyễn Thu Quỳnh1,, Nguyễn Duy Thư1, Nguyễn Khắc Tùng1, Bùi Thị Luyến1
1 Thai Nguyen University of Medicine and Pharmacy

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Abstract

Objectives: To prepare Elsholtzia Ciliata herb in capsule form to standardize dosage and be convenient to use.  Materials and methods: The herb was extracted by the Soxhlet method, the extract was concentrated by the vacuum rotary evaporation method, and then dried at 40°C. The moisture, density, and smoothness of the powder were analyzed to select hard capsule formulations. Results: Elsholtzia Ciliata herb capsules were prepared with an equivalent dose of 2 capsules/time, 3 times a day. On the chromatogram, there were traces of the same Rf value and the same color as those on the chromatogram of reference medicinal herb. Elsholtzia Ciliata herb capsule contains 0.31% total phenolics and 0.105% total flavonoids. In addition, it meets the requirements of mass uniformity, disintegration, and moisture content according to the capsule standard of Vietnam Pharmacopoeia V.

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References

1. Bộ môn Bào chế (2006), “Kỹ thuật bào chế và sinh dược học các dạng thuốc”, NXB Y học, tập II, tr.205 – 216.
2. Bộ Y tế (2018), “Dược Điển Việt Nam V”, Nhà xuất bản y học.
3. Trần Phúc Đạt (2016), “Nghiên cứu thành phần hóa học và hoạt tính sinh học trong cây Kinh giới (Elsholtzia ciliata) ở Việt Nam”, Luận văn thạc sĩ khoa học, Trường Đại học Quốc gia Hà Nội.
4. Lauryna Pudziuvelytea, Valdas Jakštas, Liudas Ivanauskasd (2018), “Different extraction methods for phenolic and volatile compounds recovery from Elsholtzia ciliata fresh and dried herbal materials”, Industrial Crops & Products (120), pp. 286–294.
5. D. Marinova, F. Ribarova, M. Atanassova (2005), “Total phenolics and total flavonoids In bulgarian fruits and vegetables”, Journal of the University of Chemical Technology and Metallurgy, Vol.40 (3), pp. 255-260.