Article Sidebar

PDF
Date Published: 27/04/2022
Abstract Views: 300
Views PDF: 197
DOI: https://doi.org/10.51298/vmj.v513i1.2340
Issue
Vol. 513 No. 1 (2022)
Section
Các bài báo
How to Cite
Ngọc Linh, P. ., & Ngọc Hà, N. . (2022). CLINICAL AND SUBCLINICAL CHARACTERISTICS OF BETA THALASSEMIA PATIENTS WITH REDUCE EF% ON DOPPLER ECHOCARDIOGRAPHY IN THAI NGUYEN CENTRAL HOSPITAL. Vietnam Medical Journal, 513(1). https://doi.org/10.51298/vmj.v513i1.2340

CLINICAL AND SUBCLINICAL CHARACTERISTICS OF BETA THALASSEMIA PATIENTS WITH REDUCE EF% ON DOPPLER ECHOCARDIOGRAPHY IN THAI NGUYEN CENTRAL HOSPITAL

Phạm Ngọc Linh1, Nguyễn Ngọc Hà1,
1 Thai Nguyen University of Medicine and Pharmacy

Main Article Content

Abstract

The aims were to describe the clinical and subclinical characteristics of beta thalassemia patients with reduce EF% on Doppler echocardiography in Thai Nguyen Central Hospital. Methods: A cross-sectional study was performed on 67 patients with thalassemia treated at the Clinical Hematology Department, Thai Nguyen Central Hospital from 1/2021 to 1/2022. Results: The female rate was higher than male rate; the majority of patients are ethnic minorities (71.6%); the age group <15 accounted for the highest percentage (50.7%), the mean age of diagnosis of the disease group was 2(±2) lower than the control group. Common clinical symptoms were: dizziness (41%) and fatigue (40%). The test showed that: mean Hb, mean Bil TT & TP, mean SGOT of the the disease group with reduced left ventricular ejection fraction lower than the control group; the ultrasound index of the disease group was also lower than the control group. There was a statistically significant difference in the mean age of diagnosis, the frequency of blood transfusions ≥5 times/year in the group of thalassemia patients with reduced left ventricular ejection fraction with the control group (p<0.05); Mean EF (53.16±1.12), mean FS (31.16±2.46) evaluating left ventricular systolic function of the disease group were lower than the control group, with p<0.05; There was a statistically significant difference between the disease group with blood ferritin ≥ 2500 ng/ml of the patient group and the control group, with p< 0.05.

Article Details

Keywords

Thalasamie, Thai Nguyen Central Hospital

References

1. Mã Phương Hạnh.., (2009). "Đặc điểm bệnh nhân thalassemia thể nặng có ứ sắt tại Bệnh viện Nhi Đồng 1", Tạp chí y học tp HCM, phụ bản tập 13 số 1, chuyên đề Nhi khoa, tr.167-173.
2. Nguyễn Việt Hà và cộng sự. (2017),"Biến đổi tim mạch ở bệnh nhân beta – thalassemia tại bệnh viện trẻ em Hải Phòng", Tạp chí nhi khoa, 10(2), p.45-49.
3. Phạm Ngọc Linh (2021), "Biến đổi hình thái và chức năng tim ở bệnh nhân beta thalassemia điều trị tại bệnh viện Trung ương Thái Nguyên năm 2020", Luận văn thạc sĩ, Đại học Y Dược Thái Nguyên.
4. Phan Hùng Việt (2016), "Nghiên cứu đặc điểm lâm sàng và xét nghiệm bệnh Thalassemia ở trẻ em tại khoa nhi Bệnh viện Trung ương Huế", Tạp chí Y Dược học Trường Đại học Y Dược Huế, 6(5).
5. Borgna-Pignatti C., Rugolotto S., et al (2004), "Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine", Haematologica, p.1187-1193.
6. Bosi G, Crepaz R, Gamberini MR, et al (2003), "Left ventricular remodelling, and systolic and diastolic function in young adults with β thalassaemia major: a Doppler echocardiographic assessment and correlation with haematological data", Heart, p.762-766.
7. Davis BA, O’Sullivan C, Jarritt PH, Porter JB (2004), "Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major", Blood, p.263-269.
8. Noori NM, Mehralizadeh S (2010), "Echocardiographic evaluation of systolic and diastolic heart function in patients suffering from beta-thalassemia major aged 5-10 years at the Zahedan Research Center for Children and Adolescent Health", Anadolu Kardiyol Derg AKD Anatol J Cardiol, 150-153
9. Thalassemia Internation Federation annual report (2013).