EFFICACY OF RESCUE THERAPY THERAPY FOR HELICOBACTER PYLORI ERADICATION AFTER FAILED WITH BISMUTH CONTAINING THERAPY

Nguyễn Công Long1,, Nguyễn Văn Khanh1
1 Department of Gastroenterology and Hepatology, Bach Mai Hospital

Main Article Content

Abstract

Objective: A rescue treatment schedule has been reported to be effective. This study aimed to assess the efficacy and safety of rescue regime in patients who failed previous therapies. Subjects and methods: Thirty patients with duodenal ulcer with H. pylori positive failed with bismuth containing therapy were enrolled to a 14-day rescue regimen 40mg of esomeprazole, 1g of amoxicillin, 500mg of metronidazole and 500 mg levofloxacin twice daily for 14 days. Results: The eradication rate achieved with the sequential regimen was 93.3%. The incidence of minor side effects was 36.7% with fatigue. Conclusions: Rescue therapy was significantly therapy for eradicating H. pylori infection after failed previous therapy.

Article Details

References

1. Fock, K.M., et al., Second Asia-Pacific Consensus Guidelines for Helicobacter pylori infection. J Gastroenterol Hepatol, 2009. 24(10): p. 1587-600.
2. Fock, K.M. and T.L. Ang, Epidemiology of Helicobacter pylori infection and gastric cancer in Asia. J Gastroenterol Hepatol, 2010. 25(3): p. 479-86.
3. Cammarota, G., et al., Efficacy of two one-week rabeprazole/levofloxacin-based triple therapies for Helicobacter pylori infection. Aliment Pharmacol Ther, 2000. 14(10): p. 1339-43.
4. Gatta, L., et al., Sequential therapy or triple therapy for Helicobacter pylori infection: systematic review and meta-analysis of randomized controlled trials in adults and children. Am J Gastroenterol, 2009. 104(12): p. 3069-79; quiz 1080.
5. Furuta, T., et al., Effects of genotypic differences in CYP2C19 status on cure rates for Helicobacter pylori infection by dual therapy with rabeprazole plus amoxicillin. Pharmacogenetics, 2001. 11(4): p. 341-8.
6. Miwa, H., et al., Efficacy of reduced dosage of rabeprazole in PPI/AC therapy for Helicobacter pylori infection: comparison of 20 and 40 mg rabeprazole with 60 mg lansoprazole. Dig Dis Sci, 2000. 45(1): p. 77-82.