HIỆU QUẢ CỦA LIỆU PHÁP ĐIỀU TRỊ THOÁI HÓA KHỚP GỐI BẰNG HUYẾT TƯƠNG GIÀU TIỂU CẦU KẾT HỢP VỚI TẾ BÀO GỐC TRUNG MÔ TỪ MÔ MỠ TỰ THÂN TẠI NGHỆ AN

Abstract

Aim: To evaluate the effectiveness of platelet-rich plasma therapy combined with mesenchymal stem cells from autologous adipose tissue in the treatment of knee osteoarthritis. Objects and methods: 30 patients, 26 female, 4 male, mean age 58.63 ± 11.11, disease duration 5.3 ± 4.6 years, respectively 60 knee joints were diagnosed as degenerative according to American Society of Rheumatology (ACR), stages II - III according to Kellgren and Lawrence. All were injected with autologous platelet-rich plasma mixture extracted by PRP kit, APC 30 PRP PRCEDURE PRAK and mesenchymal  stem cells from autologous abdominal adipose extracted by ADI-25-01 ADIPOSEPRCEDURE PRAK kit with machine Harvest smart stem cell separation of the company TERUMO BCT- USA. Results: After treating 12 months: The pain level through the VAS of the right knee joint decreased from 6.0 ± 1.28 before treatment to 1.9 ± 0.3; VAS score of left knee joint decreased from 6.43±1.19 to 2.25±0.43. Total Lequene score of right knee joint decreased from 16.04±1.57 before treatment to 4.31±1.04; left knee joint decreased from 17.52±1.74 to 5.15±1.48. Total WOMAC score for right knee joint decreased from 55.93±5.56 to 10.37±1.56; left knee joint decreased from 53.97±5.57 to 10.07±1.59. There were 52/60 (86.77%) joints with cartilage thickness change and the patellar cartilage thickness increased from 1.56 ± 0.25mm before treatment to 1.64 ± 0.21mm. Conclusion: The treatment of knee osteoarthritis by platelet-rich plasma combined with mesenchymal stem cells from autologous adipose tissue is effective in reducing pain, improving movement and walking function of patients compared with before treatment; improve articular cartilage thickness articular cartilage thickness on magnetic resonance thereby improving the mobility function of the knee joint.