NGHIÊN CỨU PHÂN LOẠI MÔ BỆNH HỌC VÀ MỘT SỐ DẤU ẤN HÓA MÔ MIỄN DỊCH CỦA U THẦN KINH ĐỆM LAN TỎA CỦA NÃO THEO PHÂN LOẠI CỦA TỔ CHỨC Y TẾ THẾ GIỚI NĂM 2007

Abstract

Objection: Determine the rate of the anapathological types of the diffuse  cerebral gliomas based on the WHO in 2007, and analyze the correlation of immunohistochemical markers with the anapathological types and grades. Research material: Specimens, slides, and paraffin blocks from patient cases, which have been surgically removed from brain tumors, at the Viet Duc Hospital, from 1/2015 to 1/2020. Study method: Description of the cross-section. Analysis of disease distribution characteristics of research variables such as gender, age. Diagnosed, classified, and evaluated the malignancy of diffuse gliomas based on the classification system of the World Health Organization in 2007. Analysis of distribution characteristics of diseases of gender, age. Histopathological feature, the grading of brain tumors assessed on the scale of malignancy. Investigation of some immunohistochemical markers in brain tumors and their relationship to histopathological grade such as: IDH1, Ki67 and P53. Results: There are 216 patients, aged from 20 to 79, the age group 30-40 years, accounting for 25.5% male/female=1.16. These diffuse gliomas were mainly composed of the following three major groups: Glioblastoms was 38%, AnaplasticAstrocytoma was 14.3 %, and Anaplastic Oligodendrocytoma was 13.4 %. The most common histopathological grade was grade 4 with 38%, following this was grade 3 with 35.6%, and the least common was grade 2 with 26.4%.  The positive rate for IDH1 marker of grade 2 glioma was the highest, accounting for 89.5%. The positive rate for IDH1 marker of grade 4 glioma was the lowest, accounting for 31.7%. The positive rate for the P53 marker of glioblastoma was the highest at 81.7%. The positive rate for P53 marker of grade 2 glioma was the lowest, accounting for 54.4%. Conclusion: Diffuse gliomas occur in both sexes, male/female=1.16/1, the most duration of the age was 30-40. The three most common histopathological types of diffuse gliomas were: Glioblastoma, Anaplastic Astrocytoma, and Anaplastic Oligodendrocytoma. The most common histopathological grade was grade 4. The highest positive rate for IDH1 markerwas grade 2. The highest positive rate for P53 was grade 4 with 81.7%. The positive rate of Ki67 with grade 2 was 3.8±1.57, grade 3 was 14.6±6.01 and grade 4 was 32.4±12.90.