TÍNH ỔN ĐỊNH VÀ CÔNG HIỆU CỦA VẮC XIN SỞI DỰ TUYỂN MẪU CHUẨN QUỐC GIA VIỆT NAM

Abstract

Objectives: Assessed the stability and effectiveness of the Measles vaccine candidate for the Vietnamese national reference standard. Materials: The live attenuated measles vaccine candidate for the Vietnamese national reference standard RM-01-07 is manufactured at POLYVAC. Methods: Empirical research and Retrospective study. Results: Through the study of standard sample measles vaccine candidate for the national standard sample, we found that: there is measles virus in the vaccine, direct observation of physical properties shows that the cake is freeze-dried, evenly porous, without foreign bodies; sterile vaccines; no growth of  Mycoplasma; efficacy, thermal stability, and residual moisture are all up to WHO evaluation criteria. The production strain of measles vaccine POLYVAC - AIK-C belongs to genotype A, completely attenuated, non-toxic, unchanged in antigen. The candidate standard measles vaccine has high efficacy stability under -70⁰C storage conditions.