SURVERY OF CAUSES, CLINICAL AND SUBCLINICAL CHARACTERISTICS OF PATIENTS WITH MULTI-ORGAN FAILURE AT THAI BINH PROVINCIAL GENERAL HOSPITAL
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Abstract
Objectives: Survery of causes, clinical and subclinical characteristics of patients with multi-organ failure at Thai Binh Provincial General Hospital. Method: prospective self control study. Results: In 82 patients with multiple organ failure, the mean age was 59.4 ± 12.5 years. Male accounted for 78% and female accounted for 22%. The number of damaged organs in each patient ranged from 2 to 6 organs, of which failure of 4 organs had the highest rate (45.1%), failure of 2 organs accounted for the lowest rate (8.5%). Some of the clinical manifestations of organ damage encountered with the highest rate are: Respiratory: dyspnea (100%), rapid breathing (45.5%), mechanical ventilation (72.5%); Cardiovascular: tachycardia (88.57%); Kidney: oliguria/anuria (59.8%). Some subclinical manifestations: infected patients: 70.7% leukocytosis; 58.5% pulmonary infiltrates on X-ray; 44.6% blood culture (+) and 23% sputum culture (+). Most had a white blood cell increase of 13.69 ± 9.06 and a mild anemia with a red blood cell of 3.92 ± 0.85; Hemoglobin 113.9 ± 17.56. Most of the patients had metabolic acidosis, pH 7.16 ± 0.21 and hypoxemia P/F: 208.49 ± 85.16; Serum creatinine increased 245.17 ± 145.89mg/dL, Total Billirubin increased 55.05 ± 72.57mg/dL and blood lactate increased 10.4 ± 6.91. Among the four groups of causes of multi-organ failure, infection accounts for the highest rate (79.4%) and the main source of infection is respiratory and digestive. Conclusion: Multi-organ failure is common in elderly patients with a higher rate of males than females, with lesions in many organs with diverse clinical and subclinical manifestations and infections still being the leading cause of high rates of morbidity and mortality. multi-organ failure, so it is necessary to detect early, take preventive measures and actively treat.
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Keywords
multiple organ failure
References
2. Abdin S.M., Elgendy S.M., Alyammahi S.K., et al. (2020). Tackling the cytokine storm in COVID-19, challenges and hopes. Life Sci, 257, 118054.
3. Nguyễn Đăng Tuân, Nguyễn Gia Bình (2008), Nhận xét kỹ thuật lọc máu liên tục qua 190 lần lọc máu tại khoa điều trị tích cực bệnh viện Bạch Mai, tạp chí Y học lâm sàng số 34, trang 51-56.
4. Payen D., Mateo J., Cavaillon J.M., et al. (2009). Impact of continuous venovenous hemofiltration on organ failure during the early phase of severe sepsis: A randomized controlled trial. Crit Care Med, 37(3), 803-810.
5. Nguyễn Gia Bình, Đặng Quốc Tuấn, Đỗ Quốc Huy và cs (2013). Nghiên cứu ứng dụng một số kỹ thuật lọc máu hiện đại trong cấp cứu, điều trị một số bệnh, Đề tài cấp nhà nước, Bộ Khoa học và Công nghệ - Bộ Y tế, tr 93-100.
6. Ronco C., Tetta C., Mariano F., et al. (2003). Interpreting the Mechanisms of Continuous Renal Replacement Therapy in Sepsis: The Peak Concentration Hypothesis. Artif Organs, 27(9), 792-801.
7. Elizabeth B, Desanka D, Sanja D, Sebastiao A, Antonio, Renato G.G, Terzi (2001): “Multiple organ failure in septic patients”, Brazilian journal of infectious diseases, 5 (3): 1-8. Braz J Infect Dis, 5(3).
8. Hoàng Văn Quang (2011). Nghiên cứu đặc điểm lâm sàng và kết quả điều trị suy đa tạng ở bệnh nhân sốc nhiễm khuẩn, Luận án Tiến sĩ y học, Trường đại học Y Hà Nội.