MỐI LIÊN QUAN GIỮA KIỂU HÌNH MIỄN DỊCH CD44, ALDH VỚI ĐẶC ĐIỂM NỘI SOI VÀ MÔ BỆNH HỌC TRONG UNG THƯ BIỂU MÔ TUYẾN DẠ DÀY

Abstract

Objective: To analyze the relationship between CD44 ALDH immunophenotype, with endoscopic and histopathological characteristics in gastric adenocarcinoma. Subject and Method: This was cross-sectional descriptive study; prospective design on 121 patients with confirmed diagnosis of gastric adenocarcinoma and surgical resection of the tumor at K Hospital. Analysis of the relationship between CD44, ALDH and parameters. Result: Patients with ulcerative tumors had a higher CD44 expression rate with 86.7%, p>0.05. Patients with intestinal tumor had a higher CD44 expression rate with 67.5%, p>0.05. Patients with tumor size from 2 to < 5 cm had the highest ALDH expression rate with 77.0%, p < 0.05. Patients with poorly differentiated tumors had the highest ALDH expression rate with 58.1%, p<0.05. Patients with stage III tumor had the highest ALDH expression rate with 71.6%, p<0.05. Conclusions: CD44 expression tends to be higher in ulcerative and intestinal forms. ALDH expression differs according to endoscopic tumor size, differentiation, and disease stage.