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Date Published: 20/06/2022
Abstract Views: 251
Views PDF: 163
DOI: https://doi.org/10.51298/vmj.v514i1.2556
Issue
Vol. 514 No. 1 (2022)
Section
Các bài báo
How to Cite
Tín Nghĩa, T. ., Vân Khánh, T. ., & Huy Thịnh, T. . (2022). IDENTIFICATION OF SNCA AND PARK7 MUTATION IN PARKINSON’S DISEASE. Vietnam Medical Journal, 514(1). https://doi.org/10.51298/vmj.v514i1.2556

IDENTIFICATION OF SNCA AND PARK7 MUTATION IN PARKINSON’S DISEASE

Trần Tín Nghĩa1, Trần Vân Khánh1, Trần Huy Thịnh1,
1 Hanoi Medical University

Main Article Content

Abstract

Parkinson's disease is the second of the most common neurodegenerative disorders in the elderly after Alzheimer's. The disease characterized by the selective degeneration of substantia nigra dopaminergic neuron, leading to a decrease in dopamine content, affecting the transmission of nerve signals to ensure the normal process of muscle contraction. With the rapid growth of recent studies, genetic factors play a crucial role in the progression of Parkinson’s disease. The purpose of the research is to identify mutations of the SNCA gene and PARK7 gene of Parkinson’s patients by sequencing method. 35 Parkinson’s patients were selected in this study. Direct sequencing method was used to identify SNCA and PARK7 mutations. Results: 5,71% of cases had SNCA mutations, 2,86% of cases had PARK7 mutations, 91,43% of cases did not have mutations. The average age was 56,3±8,7. The ratio of male/female was 1,19.

Article Details

Keywords

Parkinson’s disease, mutation, SNCA gene, PARK7 gene

References

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