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Date Published: 22/06/2022
Abstract Views: 183
Views PDF: 134
DOI: https://doi.org/10.51298/vmj.v515i1.2670
Issue
Vol. 515 No. 1 (2022)
Section
Các bài báo
How to Cite
Vĩnh Niên, L. ., & Nguyệt Quỳnh Mai, N. . (2022). INVESTIGATION OF 1,5-ANHYDROGLUCITOL CONCENTRATION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS. Vietnam Medical Journal, 515(1). https://doi.org/10.51298/vmj.v515i1.2670

INVESTIGATION OF 1,5-ANHYDROGLUCITOL CONCENTRATION IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Lâm Vĩnh Niên1,, Nguyễn Nguyệt Quỳnh Mai1
1 University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

Background: 1,5-AG is a reflective of short-term blood glucose status that cannot be monitored with the HbA1c test. Objectives: To evaluate changes over time and the role of 1,5-Anhydroglucitol in glycemic control. Methods: Cross-sectional study design compared with the change of 1,5-Anhydroglucitol concentration between 2 groups of patients with diabetes (189) and without diabetes (150). Conducted at the Department of Biochemistry - Military Hospital 175 - Ho Chi Minh City from February 2020 to July 2020. Results: The mean concentration of 1.5-AG of 49 patients enrolled in the prospective study after 2 weeks was 9.4 ± 7.2 μg/ml, significantly higher than the baseline at 3. 8 ± 2.9 μg/ml. This difference is statistically significant (p < 0.001). Thus, after 2 weeks, the concentration of 1.5-AG increased by an average of 5.5 g/ml. The average glucose concentration after 2 weeks of the above group of patients was 8.4 ± 5.1 mmol/l, lower than that of the group of patients. with a baseline of 13.2 ± 8.3 mmol/l, the change in concentration was –4.8 mmol/l. There was a strong negative correlation between the concentration of 1.5-AG and HbA1c (correlation coefficient r = -0.71) (p < 0.001). There was a strong negative correlation between the concentration of 1,5-AG and glucose (correlation coefficient r = -0.62) (p < 0.001). Conclusion: The change, rapid response of 1.5-AG after 2 weeks of treatment shows the short-term glycemic control ability of 1.5-AG compared with other glycemic indices.

Article Details

Keywords

Diabetes, HbA1C, 1,5-Anhydroglucitol

References

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