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Date Published: 23/06/2022
Abstract Views: 527
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DOI: https://doi.org/10.51298/vmj.v515i2.2768
Issue
Vol. 515 No. 2 (2022)
Section
Các bài báo
How to Cite
Đức Phúc, N. ., Văn Thiết, N. ., Công Hoàn, D. ., & Thị Mai Thơ, N. . (2022). A NEPHROTOXIC STUDY IN PATIENTS USING COLISTIN AT THE ICU – NGHE AN GENERAL FRIENDSHIP HÓPITAL. Vietnam Medical Journal, 515(2). https://doi.org/10.51298/vmj.v515i2.2768

A NEPHROTOXIC STUDY IN PATIENTS USING COLISTIN AT THE ICU – NGHE AN GENERAL FRIENDSHIP HÓPITAL

Nguyễn Đức Phúc1,, Ngô Văn Thiết1, Dương Công Hoàn1, Nguyễn Thị Mai Thơ2
1 Nghe An Friendship General Hospital
2 Vinh Medical University

Main Article Content

Abstract

Objectives: Describe the incidence, characteristics of patients using colistin and describe the characteristics of nephrotoxicity in patients using colistin at the ICU - General Friendship Hospital Nghe An. Subjects and methods: Retrospective, descriptive and analytical study of 29 patients with indications for colistin use at the ICU - General Friendship Hospital Nghe An, from 1/2021 to 9/2021. Result: Male patients accounted for 82.8%, the average age was 62 years old. The rate of nephrotoxicity in the study was 17.2%. The average time to onset of nephrotoxicity after colistin administration was 6.2 days. The rate of occurrence of nephrotoxicity according to the levels of “Risk”, “Injury” and “Failure” is 40%, 20% and 40% respectively. Conclusion: Colistin is a drug with high nephrotoxicity and is common, so doctors should consider using it as a last resort in the treatment of multidrug-resistant Gram-negative bacteria.

Article Details

Keywords

nephrotoxicity, colistin, Nghe an General Friendship Hospital

References

1. Nation R. L., Li J., Cars O., Couet W., Dudley M. N., Kaye K.S., Mouton J. W., Paterson D. L., Tam V. H., Theuretzbacher U., Tsuji B. T., Turnidge J. D. (2015), "Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus", Lancet Infect Dis, 15(2), pp. 225-234.
2. Bialvaei A. Z., Samadi Kafil H. (2015), "Colistin, mechanisms and prevalence of resistance", Curr Med Res Opin, 31(4), pp. 707-21.
3. Pogue J. M., Lee J., Marchaim D., Yee V., Zhao J. J., Chopra T., Lephart P., Kaye K. S. (2011), "Incidence of and risk factors for colistin-associated nephrotoxicity in a large academic health system", Clin Infect Dis, 53(9), pp. 879-84.
4. Ko HJ, Jeon MH, Choo EJ, Lee EJ, Kim TH, Jun J. B., Gil H. W. (2011), "Early acute kidney injury is a risk factor that predicts mortality in patients treated with colistin", Nephron Clin Pract, 117(3), pp. c284-8.
5. Bệnh viện Bạch Mai (2018), “Hướng dẫn sử dụng colistin”.
6. Deryke C. A., Crawford A. J., Uddin N., Wallace M. R. (2010), "Colistin dosing and nephrotoxicity in a large community teaching hospital", Antimicrob Agents Chemother, 54(10), pp. 4503-5.
7. Temocin F., Erdinc S., Tulek N., Demirelli M., Bulut C., Ertem G. (2015), "Incidence and Risk Factors for Colistin-Associated Nephrotoxicity", Jpn J Infect Dis, 68(4), pp. 318-20.