NHẬN XÉT KẾT QUẢ ĐIỀU TRỊ SAU 3 THÁNG SỬ DỤNG LIỆU PHÁP TẾ BÀO GỐC TỦY XƯƠNG TỰ THÂN HỖ TRỢ ĐIỀU TRỊ BỆNH TEO MẬT BẨM SINH TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Objective: to evaluate the early outcome of the autologous stem cell transplant (ASCT) in the treatment of billary atresia (BA) in Vietnam National Children’s Hospital. Subjects and methods: this is a prospective case-series, enrolled 31 patients diagnosed with BA, they were treated with Kasai surgery in combination with ASCT in Vietnam National Children’s Hospital from May 2021 to April 2022. Results: 31 patients were enrolled in the study, amongst those there was only 1 patient who did not fully follow the research. The ratio of male: female was 1:1. The mean age at the time of surgery is 78.8 days old. Prior to the treatment, 100% of the patient had jaundice and white or pale stool; both of these two signs were reduced at 3 months post-op, respectively (p < 0.001). There is a statistically significant difference in the level of total billirubin, conjugated billirubin, ALP and GGT between pre-op and 3-month-post-op (p < 0.01, p < 0.01, p < 0.01 and p < 0.05, respectively). At 3-month post-op, 40% of the patients had complete bile flow, 61.29% of the patients suffered from cholangitis. The median of APRI score of the pre and post-op was 0.82 and 1.16, respectively (p > 0.05); the mean PELD score of the pre-surgery and post-surgery was 9,26 and 3.83, respectively (p < 0.05). Conclusion: there is a significant improvement in the clinical manifestation, laboratory findings and PELD score after the ASCT in the treatment of BA. In the future, we would like to conduct  a similar research with a bigger population and longer follow-up duration in order to fully evaluate the outcome of this therapy.