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SURVEY ON THE CONCENTRATION AND RATE OF PLASMA HOMOCYSTEIN VARIATION IN PATIENTS WITH TYPE 2 DIABETES
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Abstract
Objective: To survey the concentration and rate of plasma homocysteine (Hcy) variation in patients with type 2 diabetes. Subjects and methods: 395 patients with type 2 diabetes diagnosed for the first time or previously diagnosed were in inpatient treatment at the National Hospital of Endocrinology. In addition to basic tests for diagnosis and assessment of patients, plasma Hcy levels were also quantified by turbidity measurement method on automatic machine AU5800 of Beckman Coulter. The reference value of normal Hcy concentration is 5-12 µmol/l. The results showed that: the mean plasma Hcy concentration was 10.23±4.19 µmol/l. The rate of patients with increased Hcy was 25.7%. The concentration of Hcy increases gradually with age and time of disease detection and is higher in men than in women. There was no significant difference in Hcy concentration between patients with the first diagnosis and those previously diagnosed. Conclusion: The concentration of Hcy in patients with type 2 diabetes increased related to age, sex, and disease detection time. This is a valuable biomarker if determined to be associated with other factors of patients.
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Keywords
Type 2 diabetes mellitus, homocysteine, disease detection time
References
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