ASSESSMENT OF THE TREATMENT RESULTS AND BRAIN PROTECTION EFFECTS OF THE 33°C TARGETED HYPOTHERMIA TREATMENT IN THE TREATMENT OF COMA PATIENTS AFTER CARDIAC ARREST
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Abstract
Purposes: To evaluate the therapeutic and brain-protective effects of the 33°C targetted hypothermia method in the treatment of comatose patients after out-of-hospital cardiac arrest. Subjects and methods: A controlled intervention study on 136 comatose patients after out-of-hospital cardiac arrest who were successfully resuscitated with return of spontaneous circulation, 68 patients received 33°C target hypothermia, 68 patients Retrospective control group routine treatment at A9 emergency department, Bach Mai Hospital from January 2013 to January 2020. Results: Survival was higher in the 33°C target hypothermia group than in the control group at discharge (58.8% vs 33.8%; p= 0.003) as well as at 6 months (51.5% vs 10.3%; p < 0.001). The good neurological outcome was higher in the hypothermic group than in the control group at 30 days (36.7% vs 10.3%; p < 0.001) as well as at 6 months (39.7% vs. 3%; p<0.001). Conclusions: Targeted hypothermia treatment of 33°C improves survival as well as good neurological outcomes for comatose patients after out-of-hospital cardiac arrest.
Keywords
Cardiac arrest, Sudden cardiac death, Cardiopulmonary resuscitation, Therapeutic hypothermia, The Cerebral Performance Category (CPC) score
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References
2. Callaway C. W., Donnino M. W., Fink E. L. và cộng sự (2015). Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation, 132 (18 Suppl 2), S465-482.
3. Edgren E., Hedstrand U., Kelsey S. và cộng sự (1994). Assessment of neurological prognosis in comatose survivors of cardiac arrest. BRCT I Study Group. Lancet, 343 (8905), 1055-1059.
4. Hypothermia after Cardiac Arrest Study G. (2002). Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med, 346 (8), 549-556.
5. Vattanavanit V. và Bhurayanontachai R. (2016). Clinical outcomes of 3-year experience of targeted temperature management in patients with out-of-hospital cardiac arrest at Songklanagarind Hospital in Southern Thailand: an analysis of the MICU-TTM registry. Open Access Emerg Med, 8, 67-72.
6. Writing Group M., Mozaffarian D., Benjamin E. J. và cộng sự (2016). Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation, 133 (4), e38-360.