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STUDY REGIONAL LYMPH NODES METASTASES FEATURES OF CUTANEOUS MELANOMA
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Abstract
Target: Study clinical, histopathological features and the relationship between the regional lymph nodes metastases and some clinical, pathological factors of cutaneous melanoma. Objects and methods: a retrospective, prospective study on 135 cutaneous melanoma patients in stage II, III who were treated with radical surgery at K hospital from 2013 to 2019. Results: average age 55.5 ± 14.7, common age from 40 to 70. Female/male 1.01, lower limbs 49.6%, black tumors 65.9%, superficial spreading melanoma 52.6%, regional lymph nodes metastases 48.1%. Thickness in T3, T4 96.3%, ulceration 48.1%, Clark IV,V 77.1%. Vertical growth phase 72.6%, invasion 22.2%, satellite 34.8%. The non tumor infiltrating group 88.7%. Ratio of regional lymph nodes metastases in nodular melanoma 100%, acral lentiginous melanoma 93.8%. Ratio of regional lymph nodes metastases in thickness tumor T2, T3, T4 is 0%, 19.6%, 73%, respectively. Ratio of regional lymph nodes metastases in tumors with ulceration is higher than one without ulceration, 84.6% and 14.3%, respectively. Ratio of regional lymph nodes metastases in vasive group Clark IV-V is higher than one Clark II-III, 34% and 7.7%, respectively. Ratio of regional lymph nodes metastases in vertical growth phase group is higher than radial growth phase, 31.5% and 0%, respectively. Ratio of regional lymph nodes metastases in invasion group is higher than without invasion, 100% and 33.3%, respectively. Ratio of regional lymph nodes metastases in satellite is higher than one without satellite, 85.1% and 28.4%, respectively. Ratio of regional lymph nodes metastases in miotic rate group < 1mm2 0%, 1 – 6mm2 31.8%, > 6mm2 98.1%, respectively. Ratio of regional lymph nodes metastases in dense tumor infiltrating group 6.9%, in sparse tumor infiltrating group 39.7%, in group without tumor infiltrating 88.7% (p < 0.05). Conclusion: Average age 55.5 ± 14.7, common age from 40 to 70, female/male is 1.01. Lower limbs 49.6%, black tumors 65.9%. Superficial spreading melanoma 52.6%. Lymph nodes metastases 48.1%, T3, T4 96.3%, ulceration 48.1%, Clark IV, V 77.1%. Vertical growth phase 72.6%, sparse tumor infiltrating 46.7%. Ratio of regional lymph nodes metastases relates to tumor location, histopathology, thickness, ulceration, Clark, stage, invasion, satellite, tumor infiltrating.
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Keywords
Cutaneous melanoma, histopathological
References
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