ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ CHỨC NĂNG THẬN CỦA BỆNH NHÂN THẬN ĐA NANG

Nguyễn Thị Thùy Linh1,, Nguyễn Thị Hương2, Đỗ Gia Tuyển3
1 Bac Ninh General Hospital
2 Bach Mai Hospital
3 Hanoi Medical University

Main Article Content

Abstract

Objective: To describe the clinical, laboratory and kidney function in polycystic kidney disease patients. Methods: A cross-sectional study on 115 adult outpatients and inpatients in Bach Mai hospital diagnosed with polycystic kidney disease, from August 2021 to the end of August 2022. Results: The mean age of the study subjects was 51.3+ 12.9 years. Male proportion accounted for 49,6%. Common clinical symptoms are pelvic pain (45.2%), hematuria (33.9%); dysuria (38,3%), enlarged kidneys (64.3%), hypertension (59.1); 65.0% of cases had enlarged kidneys, the average size of the largest renal cyst was 49.6mm. The proportion of patients with polycystic kidney disease with renal failure is 75.7%, in which stage 5 renal failure accounts for the highest proportion (34.8%), followed by stage 3 (26.1%). and stage 4 (14.8%). Conclusion: The proportion of patients with polycystic kidney disease with chronic renal failure accounts for a high rate, up to 75,7%. Several factors are associated with the renal failure condition including age, hypertension, large renal cyst size, and a family history of renal failure. 

Article Details

References

1. Bergmann C, Guay-Woodford LM, Harris PC, Horie S, Peters DJM, Torres VE. Polycystic kidney disease. Nat Rev Dis Primers. 2018;4(1):50. doi:10.1038/s41572-018-0047-y
2. Chapman AB, Devuyst O, Eckardt KU, et al. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. Kidney International. 2015;88(1):17-27. doi:10.1038/ki.2015.59
3. Đỗ Gia Tuyển. Bệnh Học Nội Khoa Thận - Tiết Niệu - Tập 1.; 2021.
4. Cornec-Le Gall E, Alam A, Perrone RD. Autosomal dominant polycystic kidney disease. The Lancet. 2019;393(10174):919-935. doi:10.1016/ S0140-6736(18)32782-X
5. Đinh Gia Hưng. Nghiên Cứu Đặc Điểm Lâm Sàng, Cận Lâm Sàng Bệnh Thận Đa Nang Bẩm Sinh ở Người Trưởng Thành Điều Trị Tại Khoa Thận Tiết Niệu Bệnh Viện Bạch Mai. Luận văn chuyên khoa cấp 2. ĐH Y Hà Nội; 2008.
6. Ecder T, Chapman AB, Brosnahan GM, Edelstein CL, Johnson AM, Schrier RW. Effect of antihypertensive therapy on renal function and urinary albumin excretion in hypertensive patients with autosomal dominant polycystic kidney disease. American Journal of Kidney Diseases. 2000;35 (3):427-432. doi:10.1016/S0272-6386(00) 70195-8
7. Cadnapaphornchai MA, McFann K, Strain JD, Masoumi A, Schrier RW. Prospective Change in Renal Volume and Function in Children with ADPKD. CJASN. 2009;4(4):820-829. doi:10.2215/CJN.02810608
8. Torres VE, Chapman AB, Perrone RD, et al. Analysis of baseline parameters in the HALT polycystic kidney disease trials. Kidney International. 2012;81(6):577-585. doi:10.1038/ ki.2011.411
9. Nowak KL, You Z, Gitomer B, et al. Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease. JASN. 2018;29(2):571-578. doi:10.1681/ ASN.2017070819
10. Schrier RW, Abebe KZ, Perrone RD, et al. Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease. N Engl J Med. 2014;371(24):2255-2266. doi:10.1056/NEJMoa1402685