ĐÁNH GIÁ SỰ BIẾN ĐỔI HÌNH THÁI VÀ CHỨC NĂNG TIM Ở BỆNH NHÂN THALASSEMIA TẠI TRUNG TÂM NHI KHOA BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN

Abstract

Objectives: Evaluate the morphological changes and heart function, and describes some of the factors related to the changing morphology and cardiac function in patients Thalassemia. Methods: Describe case series study. Subjects: 26 patients Thalassemia were treated at the center for Pediatric medicine - Thai Nguyen National Hospital from 2/2020 to 2/2021. Results: Radiograph, 57.7% had enlarged heart shadow; Electrocardiogram, 84.6% had tachycardia; cardiac ultrasound, 53.8% of children had mitral valve regurgitation, 30.8% had heart failure, 26,9% had decreased myocardial contractility and 19.2% had left ventricular dilatation. Elevated serum ferritin concentrations ≥ 2000ng/ml and morbidity over 5 years are risk factors for cardiac complications in patients with Thalassemia. Conclusion: Cardiovascular morphology and heart function changes in patients with Thalassemia are mainly enlarged heart, tachycardia, mitral valve regurgitation, and heart failure, decreased myocardial contractility, and left ventricular dilation. There is a relationship between serum ferritin concentration and duration of disease and cardiac complications in patients with Thalassemia.