ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ KẾT QUẢ ĐIỀU TRỊ BỆNH NHÂN NGỘ ĐỘC CẤP HÓA CHẤT DIỆT CỎ GLUFOSINAT

Abstract

Objectives: To describe the clinical characteristics, laboratory abnormalities and to assess the treatment outcomes of the patients with acute glufosinat poisoning at the Poison Control Center of Bach Mai Hospital. Subjects and Methods: A prospective observational study included 64 patients with acute glufosinat poisoning treated at Poison Control Center of Bach Mai Hospital from December 2020 to June 2022. Results: the patients’ mean age was 39.0 ± 14.1 years old. There were 46 male patients (71.9%), and 18 female patients (28.1%). The median ingested amount of glufosinat was 9 grams (interquartile range: 6-15 grams). The median of duration from ingestion to emergency department was 4.5 hours.  Gastrointestinal signs were the most commonly observed (79.4%), those often developed in the first 1 hour after ingestion, followed by neurological symptoms (40.6%). All of the seizures developed between 24 and 65 hours after ingestion. Electroencephalography findings epileptiform discharges in 9 cases (14.1%). Cardiovascular and respiratory signs accounted for 21.9% and 15.6%, respectively. Initial serum ammonia was a predictor of late neurological complications. The treatment outcomes were 96.9% survival, 3.1% sequelae. The average length of hospital stay was 5 days. Conclusion: glufosinat poisoning caused multi-organ damages, neurologic complications that may be difficult to treat due to delayed manifestations.