ĐẶC ĐIỂM LÂM SÀNG VÀ CẬN LÂM SÀNG CỦA BỆNH CROHN TRẺ EM TẠI BỆNH VIỆN NHI TRUNG ƯƠNG

Abstract

Children's Crohn's disease has diverse clinical manifestations in the gastrointestinal tract and extra-gastrointestinal tract, with complex laboratory, endoscopic and histopathological manifestations. Objectives: to describe clinical and paraclinical characteristics of pediatric Crohn's disease at the Vietnam National Children's Hospital. Materials and methods: a case series of 57 children diagnosed Crohn's disease from August, 2021 to July, 2022. Results: The male:female ratio of was 1,2:1. The median age of onset was 9 years. The most common clinical manifestations in the gastrointestinal tract were abdominal pain (80,7%), bloody stools (63.2%), straining (47,4%), anal lesions (47,4%). Commonly seen laboratory signs are anemia (75,4%), thrombocytopenia (64,9%), increased erythrocyte sedimentation rate (41.1%), increased CRP (63.2%) decreased blood albumin (45,6%), increased fecal calprotectin (68,4%). 100% of patients have lesions of the lower gastrointestinal tract with 91,1% have colonic lesions. 26,3% of patients had granulomas in histopathology, 52,6% had typical histopathological images with Crohn's disease. Conclusion: Children with Crohn's disease have diverse clinical and laboratory manifestations. There are no typical clinical symptoms or laboratory signs that are the gold standard for diagnosis.