ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG VÀ MỘT SỐ CĂN NGUYÊN CỦA BỆNH PHỔI MÔ KẼ

Abstract

Objectives: To assess clinical and subclinical characteristics and some causes of interstitial lung disease. Subjects and methods: 102 interstitial lung disease patients. Patients were scanned by high–resolution computed tomography to identify interstitial lung disease according to ATS/ERS/ALAT 2011 criteria. Research results: Shortness of breath (88,2%) was the main functional symptom. 82,4% had crackles and 29,4% muscle weakness on clinical examination. Anemia on laboratory tests had found in 41,5%. The average erythrocyte sedimentation rate in the first and second hours was 44,11 ± 30.5mm and 68.16 ± 29.15mm, respectively. The mean CRP concentration of the study group was 5.5 ± 7,71 mg/dl, and the Ferritin (ng/ml) concentration of the study group was 1261.04 ± 1623,7. Pulmonary hypertension had found in 73,7% of patients, mainly mild pulmonary hypertension (53,4%). The mean pulmonary artery pressure was 39,9 ± 17,14 mmHg. Restrictive ventilation disorder had found in 71,2%. The most common lesion on HRCT is a ground glass pattern (59.8%), followed by traction bronchiectasis (50%), interstitial pattern (45.1%), honeycombing (31,4%), reticular pattern (23.5%), and other lesions with less rate. The most common cause of interstitial lung damage is the group of connective tissue diseases, mainly polymyositis/dermatomyositis, accounting for 26,3%. In the idiopathic group, idiopathic pulmonary fibrosis was the leading cause accounting for 4.9%; less commonly, AIP and COP only accounted for 1% of each reason. The remaining Sarcoidosis (3.9%), Alveolar proteinosis (3.9%), HP (2%), Eosinophilic pneumonia, LAM, Occupational lung disease, and Erasmus syndrome account for only 1% of patients every cause. Conclusion: Interstitial lung disease is a complex disease with many etiologies. High-resolution computed tomography is an essential method in diagnosing interstitial lung disease while performing a clinical examination and selecting appropriate tests to accurately determine the etiology of interstitial lung disease to choose the proper treatment.