Article Sidebar

PDF
Date Published: 13/11/2022
Abstract Views: 267
Views PDF: 164
DOI: https://doi.org/10.51298/vmj.v519i2.3617
Issue
Vol. 519 No. 2 (2022)
Section
Các bài báo
How to Cite
Thanh Hà Tuấn, N. ., & Thị Mỹ Bình, N. . (2022). ACUTE AND SEMI-CHRONIC ORAL TOXICITY EVALUATION OF TONG VE NHAN SOFT CAPSULE IN EXPERIMENTAL ANIMALS. Vietnam Medical Journal, 519(2). https://doi.org/10.51298/vmj.v519i2.3617

ACUTE AND SEMI-CHRONIC ORAL TOXICITY EVALUATION OF TONG VE NHAN SOFT CAPSULE IN EXPERIMENTAL ANIMALS

Nguyễn Thanh Hà Tuấn1,, Ngô Thị Mỹ Bình2
1 Military Hospital 103, Vietnam Military Medical University
2 Thai Nguyen University of Medicine and Pharmacy

Main Article Content

Abstract

The article presents the evaluation of the anti-pneumonia effect of Tong ve nhan soft capsule (Vn-TVN), which produced by Vinpharma, in experimental animal. Objectives: Studying the acute toxicity and semi-permanent toxicity of Tong ve nhan soft capsule  in experimental animals. Research Methods: The method was described by Alaa N. A. Fahmi et al (2015). Research results: Vn-TVN at doses of 416 mg/kg/day and 832 mg/kg/day have anti-inflammatory effects against LPS-induced pneumonia in rats. Specifically: reducing pulmonary edema through the W/D ratio of the lung parenchyma; reduction of lung injury through histopathological assessment of the lung; reduced lung inflammation by reducing C-reactive protein in rat blood and reducing protein, cells, LDH and NOx in bronchial lavage. The difference was statistically significant compared with the model batch with p < 0.01. These effects of Vn-TVN softgels tend to be dose-responsive.

Article Details

Keywords

respiratory disease, Acute Lung Injury, Acute Respiratory Distress Syndrome, Tong ve nhan capsule

References

1. Quyết định số 141/QĐ-K2ĐT "Quyết định về việc ban hành tài liệu chuyên môn "Hướng dẫn thử nghiệm tiền lâm sàng và lâm sàng thuốc đông y, thuốc từ dược liệu" (2015).
2. Alaa N. A. Fahmi, George S. G. Shehatou ,Abdelhadi M. Shebl, Hatem A. Salem (2015), Febuxostat protects rats against lipopolysaccharide-induced lung inflammation in a dose-dependent manner, Naunyn-Schmiedeberg's Arch Pharmacol, 389 269-78
3. S. Biswas J. Bhattacharyya, and A. G. Datta (2004), Mode of action of endotoxin: role of free radicals and antioxidants, Current Medicinal Chemistry, 11 359-68
4. X. Dai C. Fu, Y. Yang, M. Lin, et al (2017), Dexmedetomidine attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress, mitochondrial dysfunction and apoptosis in rats, Molecular Medicine Reports, 15 131-8
5. Z. Dong and Y. Yuan (2018), Accelerated inflammation and oxidative stress induced by LPS in acute lung injury: Iotanhibition by ST1926, International Journal of Molecular Medicine, 41 3405-21
6. R. F. Guo and P. A. Ward (2007), Role of oxidants in lung injury during sepsis, Antioxidants & Redox Signaling, 9 (11), 1991-2002
7. S. Mehta (2005), The effects of nitric oxide in acute lung injury, Vascular Pharmacology, 390-403
8. M. O. Maybauer S. Rehberg, D. M. Maybauer, L. D. Traber, P. Enkhbaatar, and D. L. Traber (2010), The role of nitric oxide and reactive nitrogen species in experimental ARDS, Frontiers in Bioscience - Scholar, 18-29
9. Y. Ling Z. Gu, and B. Cong (2000), Peroxynitrite mediated acute lung injury induced by lipopolysaccharides in rats, Zhonghua Yi Xue Za Zhi, 80 (1), 58-61.