NGHIÊN CỨU TÁC DỤNG GIẢM ĐAU CỦA BÀI THUỐC HOÀNG KỲ QUẾ CHI NGŨ VẬT THANG TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Background: “Hoang ky que chi ngu vat thang”, a traditional remedy, is used to treatment of musculoskeletal pain in clinical practice. However, there are no experimental trials to find out the pain relief mechanism of this remedy in Vietnam. Objective: To evaluate the analgesic effect of “Hoang ky que chi ngu vat thang” remedy on white mice. Materials and Methods: Evaluation of the central analgesic effect by using the pain-induced Hotplate model and the Writhing tests model with acetic acid. Results: The group was used “Hoang ky que chi ngu vat thang” had a statistically significant greater time of pain occurrence (p < 0.05) compared to the control group and similar to the reference group (Aspegic); the number of writhing pain, during 25 minutes after acetic acid injection, in both groups with dose 1 and dose 2 were statistically significantly lower (p < 0.01), equivalent to the reference group (Aspegic). Conclusions: “Hoang ky que chi ngu vat thang” at a oral doses of 14,112 g/kg/day and 28,224 g/kg/day has good analgesic effect according to central and peripheral analgesic mechanism.