ĐÁNH GIÁ ĐỘC TÍNH CẤP CỦA BÀI THUỐC NGŨ VỊ TIÊU KHÁT THANG TRÊN ĐỘNG VẬT THỰC NGHIỆM

Abstract

Background: Ngu Vi Tieu Khat (NVTK) is a traditional medicine formula from Dr Tran Van Thoai - An Giang province regarded as an effective remedy for hyperglycemia, however, there are no experimental studies to verify the safety of this remedy. Objectives: To independently investigate the acute toxicity of the remedy NVTK on experimental animals. Materials and methods: determine the acute toxicity of the remedy by the Litchfield - Wilcoxon method on Swiss white mice. Signs of acute intoxication or fatality were monitored for 72 h after the ingestion of NVTK liquid extract. Results: administration to the mice the doses of 125g/kg, 175g/kg, 225g/kg, 275g/kg, 325g/kg and the maximal dose of 375g/kg body weight (26,573 times the therapeutic dose calculated by the corresponding dose on a human subject) the LD50 of the remedy was not determined. Conclusions: The liquid extract from the remedy of NVTK has no acute toxicity to white mice.