NGHIÊN CỨU KẾT QUẢ ĐIỀU TRỊ BỆNH NHÂN TÂM THẦN PHÂN LIỆT CÓ VÀ KHÔNG CÓ TRIỆU CHỨNG ÂM TÍNH BẰNG OLANZAPINE

Abstract

Objectives: The results of treatment in schizophrenic patients with and without  negative symptoms with olanzapine. Subject and methods: Decriptive research cross- section in 71 schizophrenic patients at the Psychiatric Department, 103 Military Hospital from January 2022 to August 2022. Results: Delusions and hallucinations in both groups decreased significantly after 3 weeks of treatment. The group without negative symptoms decreased from 97,05% to 58,82% and 35,29%; the group with negative symptoms decreased from 64,86% to 16,21% and 51,35% to 8,10%. Negative symptoms such as emotional blunting, poor seft-care, loss spririt all decreased from 54,05%, 70,3% and 86,54% to 43,24%, 21,62% and 81,08%. The mean score of PANSS scale of both groups of patients decreased in all items such as total PANSS score, P-PANSS, N-PANSS, Par-PANSS, Dep-PANSS, the difference was statistically significant with p<0,05. Conclusion: After 3 weeks of treating schizophrenia patients with and without negative symptoms with olanzapine, the delusions, hallucinations and negative symptoms were all significantly reduced. The mean score of PANSS scales decreased in all items.