Article Sidebar

PDF
Date Published: 13/11/2022
Abstract Views: 202
Views PDF: 109
DOI: https://doi.org/10.51298/vmj.v519i2.3665
Issue
Vol. 519 No. 2 (2022)
Section
Các bài báo
How to Cite
Tất Kiên, N. ., Anh Tuấn, T. ., & Thị Kiều My, T. . (2022). ASSOCIATION BETWEEN FIBRINOGEN PLASMA LEVEL AND MORTALITY IN SEVERE SEPSIS PEDIATRIC PATIENTS. Vietnam Medical Journal, 519(2). https://doi.org/10.51298/vmj.v519i2.3665

ASSOCIATION BETWEEN FIBRINOGEN PLASMA LEVEL AND MORTALITY IN SEVERE SEPSIS PEDIATRIC PATIENTS

Nguyễn Tất Kiên1, Tạ Anh Tuấn2,, Trần Thị Kiều My1
1 Hanoi Medical University
2 Vietnam National Children's Hospital

Main Article Content

Abstract

In severe sepsis, immune response, cytokines and inflammatory mediators can active coagulation leading to coagulation disorders all over the body. In recent studies, Fibrinogen has been reported as a biomarker of coagulopathy. Objectives: to analyze plasma fibrinogen levels in severe sepsis children admitted to PICU and elucidate the relationship between fibrinogen levels and mortality in pediatric patients with severe sepsis. Methods: Pediatric patients diagnosed with severe sepsis according to IPSCC 2005, without chronic diseases, admitted to the PICU from June 2021 to the end of July 2022 were included in the study. Clinical and laboratory parameters as well as treatment outcomes at the hospital were collected and analyzed. Results: A total of 69 patients were included in the study. The overall in-hospital mortality rate was 21.7% (15/69). Fibrinogen plasma level were significantly lower in non-survivors than in survivors. Furthermore, the area under the curve (ROC) for fibrinogen in predicting hospital mortality was 0.780 (95% CI: 0.711-0.850). Conclusion: Fibrinogen is a valuable prognostic biomarker for severe bacterial infections in children. Hypofibrinogen on admission to PICU are strongly associated with an increased risk of mortality in severe sepsis.

Article Details

Keywords

severe sepsis, fibrinogen, mortality, prognostic biomarker

References

1. Goldstein B, Giroir B, Randolph A, International Consensus Conference on Pediatric Sepsis. International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med. 2005;6(1):2-8. doi:10.1097/ 01.PCC.0000149131.72248.E6
2. Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6(3):223-230. doi:10.1016/S2213-2600 (18)30063-8
3. Matsubara T, Yamakawa K, Umemura Y, et al. Significance of plasma fibrinogen level and antithrombin activity in sepsis: A multicenter cohort study using a cubic spline model. Thromb Res. 2019;181:17-23. doi:10.1016/j.thromres.2019.07.002
4. Mitra P, Guha D, Nag SS, Mondal BC, Dasgupta S. Role of Plasma Fibrinogen in Diagnosis and Prediction of Short Term Outcome in Neonatal Sepsis. Indian J Hematol Blood Transfus. 2017;33(2):195-199. doi:10.1007/s12288-016-0683-x
5. Vekaria-Hirani V, Kumar R, Musoke RN, Wafula EM, Chipkophe IN. Prevalence and Management of Septic Shock among Children Admitted at the Kenyatta National Hospital, Longitudinal Survey. Int J Pediatr. 2019;2019:1502963. doi:10.1155/2019/1502963
6. Andreotti F, Burzotta F, Maseri A. Fibrinogen as a marker of inflammation: a clinical view. Blood Coagul Fibrinolysis. 1999;10 Suppl 1:S3-4.
7. Lorente JA, García-Frade LJ, Landín L, et al. Time course of hemostatic abnormalities in sepsis and its relation to outcome. Chest. 1993;103(5):1536-1542. doi:10.1378/chest.103.5.1536
8. Tang X, Shao L, Dou J, et al. Fibrinogen as a Prognostic Predictor in Pediatric Patients with Sepsis: A Database Study. Rakonczay Jr Z, ed. Mediators of Inflammation. 2020;2020:9153620. doi:10.1155/2020/9153620