MỘT SỐ YẾU TỐ NGUY CƠ MẮC HỘI CHỨNG NGỪNG THỞ TẮC NGHẼN KHI NGỦ Ở BỆNH NHÂN BỆNH PHỔI TẮC NGHẼN MÃN TÍNH NHẬP VIỆN TẠI TRUNG TÂM HÔ HẤP - BỆNH VIỆN BẠCH MAI

Abstract

Objectives: Overlap syndrome refers to obstructive sleep apnea (OSA) combined with chronic obstructive pulmonary disease (COPD), and has worse outcomes than either condition alone. We aimed to evaluate the prevalence and possible predictors of overlap syndrome. Methods: This cross-sectional study included ninety patients with COPD who performed spirometry and polysomnography in Respiratory Centre, Bach Mai Hospital. Risk factors for COPD coexisting OSA were identified by univariate and multivariate logistic regression analyses. Results:  In the total of ninety patients, 56 patients (62.2%) had overlap syndrome. There were no significant differences in age, sex ratio, FVC % pred, FEV1 % pred, and prevalence of diabetes in the two groups (all p>0,05). CAT Score, mMRC score, the frequency of acute exacerbation in the past year, the frequency of hospitalization in the past year, body mass index (BMI), neck circumference, waist circumference, Epworth Score, STOP-BANG version Vietnam Score, pulmonary artery pressure, the prevalence of hypertension were all significantly higher in the COPD-OSA group compared with the COPD group (p<0.05). STOP-BANG version Vietnam was an independent risk factor for OSA in COPD patients (p<0.05). Conclusion: Patients with overlap syndrome had worse quality of life,  poorer clinical outcomes and more daytime sleepiness than patients with COPD alone.  STOP-BANG was an independent risk factor for OSA in patients with COPD.