NGHIÊN CỨU GIÁ TRỊ CHỈ SỐ NLR, PLR TRONG DỰ BÁO ĐÁP ỨNG ĐIỀU TRỊ UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ VỚI PHÁC ĐỒ HÓA CHẤT CÓ PLATINUM

Abstract

Objectives: Determining the optimal threshold value of pretreatment NLR and PLR index in predicting treatment response in stage IV NSCLC patients who received platinum-based chemotherapy and association with clinical and subclinical characteristics. Subjects and methods: A retrospective and prospective descriptive study on 53 stage IV NSCLC patients who received platinum-based chemotherapy regimens at the Oncology Center - Military Hospital 103 and the Oncology Department - National Lung Hospital from January 2019 to August 2022. Results: the threshold value for predicting the chemical treatment response of pretreatment NLR was 3.75, and that pretreatment PLR was 194. Patients with high NLR, PLR had significantly higher PS and worse responses to the treatment than those with low NLR, PLR (p < 0.01). The proportion of men and right lung tumors in the PLR group ≥ 194 was significantly higher than in the PLR group < 194 respectively with p = 0.019; p= 0.018. Conclusion: Pretreatment NLR and PLR indexes can predict treatment outcomes in stage IV NSCLC patients who received platinum-based chemotherapy regimens.