ĐẶC ĐIỂM NHẠY CẢM KHÁNG SINH VÀ KẾT QUẢ ĐIỀU TRỊ NHIỄM TRÙNG CỔ SÂU DO TÁC NHÂN KLEBSIELLA PNEUMONIAE

Abstract

Background: Klebsiella pneumoniae is the most common gram- negative bacterial pathogen in deep neck infection. K. pneumoniae has multi- drug resistant strains, which is a challenge of choosing an effective antibiotic. Objectives: Investigating the antibiotic sensitivity pattern and outcome of deep neck infection caused by K. pneumoniae pathogen in Cho Ray hospital from 06/2021 to 06/2022. Methods: Description of 46 patients with deep neck infection caused by K. pneumoniae in Cho Ray hospital from 06/2021 to 06/2022. Results: K. pneumoniae was highly sensitive to Carbapenems (93.5- 95.7%), Aminoglycosides (93.3- 93.5%), Cefoperazone/ Sulbactam (91.3%) and Tigecycline (91.3%). K. pneumoniae resistant to multiple antibiotics accounted for 32.6%, which included MDR phenotype (26.1%) and XDR phenotype (6.5%). MDR phenotype (3/12 isolates produced ESBL) was sensitive to Carbapenems. Carbapenem-resistant K. pneumoniae were only sensitive to Tigecycline. The rate of severe deep neck infection was 8,4%. Conclusions: In deep neck infection, K. pneumoniae remained sensitive to several antibiotics. There was an emergence of multi-drug resistant strains. Multi-drug resistant K. pneumoniae strains were mostly sensitive to Carbapenem. Carbapenem-resistant K. pneumoniae was only sensitive to Tigecycline. The rate of severe deep neck infection was high.