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Date Published: 10/02/2023
Abstract Views: 380
Views PDF: 283
DOI: https://doi.org/10.51298/vmj.v520i1B.3896
Issue
Vol. 520 No. 1B (2022)
Section
Các bài báo
How to Cite
Nguyễn, . H. L. T., Lê , M. T., Nguyễn , T. D. H., Nguyễn, . T. D., Trương , M. N., Trương , V. Đạt, & Lê , M. T. (2023). STIMULTANEOUS DETERMINATION OF NARINGIN AND TWO PRESERVATIVES DEVELOPMENT IN YOUNG POMELO EXTRACT. Vietnam Medical Journal, 520(1B). https://doi.org/10.51298/vmj.v520i1B.3896

STIMULTANEOUS DETERMINATION OF NARINGIN AND TWO PRESERVATIVES DEVELOPMENT IN YOUNG POMELO EXTRACT

Hữu Lạc Thủy Nguyễn1,, Minh Tài Lê 2, Thị Diệu Hiền Nguyễn 1, Thái Dương Nguyễn3, Minh Nhựt Trương 1, Văn Đạt Trương 1, Minh Trí Lê 1
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 The Institute for Drug Testing of Ho Chi Minh City
3 Hong Bang International University

Main Article Content

Abstract

Objectives: To develop an analytical methodology to simultaneously determine naringin and two preservatives (sodium benzoate and potassium sorbate) in extract of young pomelo. Subjects and methods: Naringin, sodium benzoate and potassium sorbate in young pomelo extract were determined by HPLC method. Results: Chromatographic separation was made with C18 column using acetonitrile – acetic acid 0.1 % (20 : 80) as the mobile phase at 1,0 ml/min and detected at 235 nm. The process was validated the system suitsability; selectivity; linearity range of naringin (10.0 – 500.0 (ppm); y = 9902.5x; R2 = 1.0000), potassium sorbate (0.4 – 20.0 (ppm); y = 34597x; R2 = 1.0000), and sodium benzoate (0.4 – 20.0 (ppm); y = 35395x; R2 = 1.0000); precision of both three compounds with RSD < 2.0%; and accuracy with recovery ratio in 98 – 102 (%). Conclusion: The process could be applied to determine the content of marker and preservatives in young pomelo extract.

Article Details

Keywords

naringin, sodium benzoate, potassium sorbate, young pomelo extract, HPLC.

References

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