Article Sidebar

PDF
Date Published: 10/02/2023
Abstract Views: 269
Views PDF: 147
DOI: https://doi.org/10.51298/vmj.v520i1B.3907
Issue
Vol. 520 No. 1B (2022)
Section
Các bài báo
How to Cite
Hoàng , T. H., Nguyễn , T. G., Nguyễn , L. T., & Vũ , N. Định. (2023). THE KINETICS AND RELATIONSHIP OF INTERLEUKIN-6 SERUM TO THE COMPLICATION, MORTALITY AFTER SURGERY PROXIMAL FEMUR FRACTURE IN ELDERLY PATIENTS. Vietnam Medical Journal, 520(1B). https://doi.org/10.51298/vmj.v520i1B.3907

THE KINETICS AND RELATIONSHIP OF INTERLEUKIN-6 SERUM TO THE COMPLICATION, MORTALITY AFTER SURGERY PROXIMAL FEMUR FRACTURE IN ELDERLY PATIENTS

Thế Hùng Hoàng 1,, Trường Giang Nguyễn 2, Lĩnh Toàn Nguyễn 1, Nhất Định Vũ 3
1 Vietnam Military Medical University
2 Department of Military Medicine
3 103 Military Hospital

Main Article Content

Abstract

Objective: to evaluate the kinetics and relationship of interleukin-6 serum to the complication, mortaliy after surgery proximal femur fracture in elderly patients. Material and methods: 60 patients were age > 60 years old operated for fracture of proximal femur between april 2020 and January 2021 in the department joint surgery – centre trauma and orthropaedic – Military hospital 103. Results: IL-6 values increase rapidly after surgery, peaking on 1 day postoperative were 40,65pg/ml, then decline to plateau and same preoperatve on 7 days postoperative. CRP level on 1 day postoperative were most important to predict complications after surgery, area under curve were 0.729 (p=0,019), cut-off point 36.9pg/l, se 55.5%, sp 87.5%. IL-6 level on 1 day postoperative were most important to predict mortality after surgery, area under curve were 0.848 (p=0,011), cut-off point 18.97g/l, se 100%, sp 71.4%. Conclusion: The serum I-6 value increased rapidly after surgery, reached peak on 1 day postoperative, then gradually decreasing until the 7 days postoperative to the same value before surgery. Serum I-6 level had predicting value complication and mortality after surgery proximal femur fracture in elderly patients.

Article Details

Keywords

Interleukin-6, proximal femur fracture.

References

1. Dhanwal D.K., Harvey N.C., et al., (2011) Epidemiology of hip fracture: Worldwide geographic variation. India n journal of orthopaedics. 45(1): p. 15-22.
2. Volpin G., et al., (2014) Cytokine levels (IL-4, IL-6, IL-8 and TGFbeta) as potential biomarkers of systemic inflammatory response in trauma patients. International orthopaedics. 38(6): 1303-9.
3. Kazmi S.S., Stranden E., Kroese A.J., et al., (2010) Pro-inflammatory interleukins in patients operated on for proximal femur fracture. Scand J Clin Lab Invest. 70(3): 158-63.
4. Lim S.J., Lee J.H., et al., (2018) Different Kinetics of Perioperative CRP after Hip Arthroplasty for Elderly Femoral Neck Fracture with Elevated Preoperative CRP. BioMed Research Internationa. 2018: 1-8.
5. Sun T., Liu Z., et al., (2011) Plasma concentrations of pro- and anti- inflammatory cytokines and outcome prediction in elderly hip fracture patients. Injury. 42(7): 707-13.
6. Saribal D., Erdogan S., Bahtiyar N., Caglar Okur S., Mert M., (2019) Inflammatory cytokines IL-6 and TNF-α in patients with hip fracture. Osteoporosis International. 30(5): 1025–1031.
7. Kazmi S.S., Kroese A.J., et al., (2010) Pro-inflammatory interleukins in patients operated on for proximal femur fracture. Scandinavian journal of clinical and laboratory investigation. 70(3): 158-63.
8. Yichayaou Beloosesky, Avital Hershkovitz, Joseph Grinblat A.P., Vivian Barak, (2007) Cytokines and C-Reactive Protein Production in Hip-Fracture-Operated Elderly Patients. Journal of Gerontology: MEDICAL SCIENCES. 62A(4): 420–426.
9. Chen X.X., Li J., et al., (2016) Relationship between Inflammatory Response and Estimated Complication Rate after Total Hip Arthroplasty. Chin Med J (Engl). 129(21): 2546-2551.