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Date Published: 15/02/2023
Abstract Views: 601
Views PDF: 160
DOI: https://doi.org/10.51298/vmj.v521i2.4038
Issue
Vol. 521 No. 2 (2022)
Section
Các bài báo
How to Cite
Nguyễn, T. D., & Nguyễn, T. H. (2023). HISTOPATHOLOGICAL FEATURES OF INTRAHEPATIC CHOLANGIOCACINOMA ACORDING TO WHO 2019 IN BACH MAI HOSPITAL FROM 2019 TO 2022. Vietnam Medical Journal, 521(2). https://doi.org/10.51298/vmj.v521i2.4038

HISTOPATHOLOGICAL FEATURES OF INTRAHEPATIC CHOLANGIOCACINOMA ACORDING TO WHO 2019 IN BACH MAI HOSPITAL FROM 2019 TO 2022

Thị Duyên Nguyễn1,2,, Thúy Hương Nguyễn2
1 Bach Mai Hospital
2 Hanoi Medical University

Main Article Content

Abstract

Introduction: Intrahepatic cholangiocarcinoma (ICC) is a heterogeneous group of malignancies, ranking second in malignancies of the liver after hepatocellular carcinoma. In 2019, the World Health Organization (WHO) released a new classification including two main groups: large duct type ICC and small duct type ICC and rare subtypes. Objectives: Determine the rate of histological types of intrahepatic cholangiocarcinoma according to WHO 2019 and compare the two main histological types with some histopathological-clinical characteristics. Methods: Including 34 cases of ICC were operated at Bach Mai hospital from January 2019 to June 2022. Research results: Large duct type accounted for 41.2%, small duct type 50.0%, 02 cases of adenosquamous carcinoma and 01 case of lymphoepithelioma-like carcinoma. Moderately differentiated tumors accounted for 61.8% and poorly differentiated tumors accounted for 38.2%. pT1 was dominant with 73.5%. The rate of lymph node metastasis was 26.5%, vascular invasion was 20.6% and perineural invasion was 50.0%. Large duct type ICCs were associated with higher perineural invasion (p=0.020) and mean preoperative serum CA19-9 levels were several times higher than those of small duct type (p<0.001). No relationship was found between histopathological subtypes with factors such as tumor size, histological grade, pT, lymph node metastasis and vascular invasion (p> 0.05). Conclusion: Large duct type accounted for 41.2%, small duct type 50.0%. Large duct type ICCs are associated with perineural invasion and mean preoperative serum CA19-9 levels are higher than those of small duct type.

Article Details

Keywords

Intrahepatic cholangiocarcinoma, histopathology, Large bile ducts, Small bile ducts

References

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