KẾT QUẢ ĐIỀU TRỊ UNG THƯ LƯỠI CT3-4N0-1M0 BẰNG HÓA CHẤT BỔ TRỢ TRƯỚC PHẪU THUẬT TẠI BỆNH VIỆN K

Abstract

Objectives: This study was conducted to report clinicals, subclinicals and the results of treatment neoadjuvant chemotherapy followed by surgery in stage cT3-4N0-1M0 tongue cancer patients at Vietnam national cancer hospital. Patients and methods: A retrospective and prospective descriptive study on 50 patients with stage cT3-4N0-1M0 tongue cancer receiving neo-adjuvant chemotherapy followed by surgery at K Hospital from 1/2015 to 12/2021. Results: Mean age 54.5; male/female is 4,5/1; diagnose stage T3 (46%), T4 (54%), N0 (42%), N1 (58%); rate of regimens using CF (24%), TC (54%), TCF (22%); The main surgical methods were half-tongue resection and cervical lymphadenectomy (66%); the rate of complete response on histopathology of the regimens CF (16.7%), TC (18.5%), TCF (27%), respectively; the 5-year disease-free survival rate was 32.7% and the 5-year overall survival rate was 35.5%, the disease-free survival and overall survival of the T3 stage group were higher than T4 and N0 were higher than N1; The group of patients with complete histopathological response after neoadjuvant chemotherapy had better disease-free and overall survival. Conclusion: Preoperative chemotherapy helps to reduce the disease stage and facilitate surgery. The 5-year disease-free survival time and the 5-year overall survival at this stage are still modest, less than 40%. The group of patients who had a complete response after preoperative chemotherapy had benefits in disease-free survival and overall survival.