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Date Published: 19/02/2023
Abstract Views: 255
Views PDF: 153
DOI: https://doi.org/10.51298/vmj.v522i2.4326
Issue
Vol. 522 No. 2 (2023)
Section
Các bài báo
How to Cite
Hà , H. H. H. ., Lê, H., Trần, K. C. ., & Nguyễn, T. N. Q. . (2023). CLINICAL, PARACLINICAL FEATURES AND IDENTIFICATION OF EGFR-T790M MUTATIONS CAUSING FIRST-GENERATION EGFR-TKIS RESISTANCE IN PATIENTS WITH NON-SMALL CELL LUNG CANCER BY USING LIQUID BIOPSY. Vietnam Medical Journal, 522(2). https://doi.org/10.51298/vmj.v522i2.4326

CLINICAL, PARACLINICAL FEATURES AND IDENTIFICATION OF EGFR-T790M MUTATIONS CAUSING FIRST-GENERATION EGFR-TKIS RESISTANCE IN PATIENTS WITH NON-SMALL CELL LUNG CANCER BY USING LIQUID BIOPSY

Hữu Hoàng Hải Hà 1,, Hoàn Lê1,2, Khánh Chi Trần1,2, Thị Như Quỳnh Nguyễn3
1 Hanoi medical university
2 Hanoi medical university hospital
3 Hanoi medical univerity hospital

Main Article Content

Abstract

Objectives: To investigate clinical and laboratory characteristics to determine the status of EGFR-T790M mutations causing first-generation resistance to EGFR-TKIs in patients with non-small cell lung cancer by liquid biopsy technique. Subjects: Including 31 patients diagnosed with EGFR-mutated non-small cell lung cancer (+) who received first-step treatment with first-generation EGFR-TKIs, and had liquid biopsies for EGFR-T790M mutations. Result: The study patients were mainly over 60 years old (64.5%) in which the male: female ratio was approximately equal; up to 58.1% of the patients did not smoke. The mean time of emergence of resistance to 1st generation TKIs: 11.9 ± 3.4 months (ranged from 7-20 months). Fatigue (96.8%) and weight loss (87.1%) were systemic symptoms accounting for the highest proportion. Chest pain (77.4%) was the most common respiratory symptom; hemoptysis (12.9%) was the least common. The number of patients with tumor sizes from 2-3cm is the highest, accounting for 32.3%, up to 9.7% of patients with tumor size >7cm. EGFR-T790M mutations detected by liquid biopsy method was 35.5%; up to 64.5% of patients had advanced disease, but liquid biopsy results did not have EGFR-T790M gene mutations. Median progression-free survival between the group carrying the EGFR-T790M mutation (11.82 months; 95% CI 9.22-14.42) and the group not carrying the EGFR-T790M mutation (11.95 months); 95%CI 10.44-13.46) there was no statistically significant difference. Conclusion: The rate of patients with EGFR-T790M mutation by liquid biopsy is somewhat higher than in other studies worldwide. No factors affecting the occurrence of EGFR-T790M mutations have been recorded, nor have they been recorded for this mutation.

Article Details

Keywords

EGFR-T790M, non-small cell lung cancer, EGFR-TKI

References

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