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Date Published: 19/02/2023
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DOI: https://doi.org/10.51298/vmj.v522i2.4366
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Vol. 522 No. 2 (2023)
Section
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How to Cite
Dương , T. T. L. ., & Lê, H. . (2023). IDENIFYING EML4-ALK FUSION GENE AND THE CORRELATION BETWEEN EML4-ALK FUSION GENE AND THE CLINICOPATHOLOGICAL CHARACTERISTIC IN NON SMALL CELL LUNG CANCER. Vietnam Medical Journal, 522(2). https://doi.org/10.51298/vmj.v522i2.4366

IDENIFYING EML4-ALK FUSION GENE AND THE CORRELATION BETWEEN EML4-ALK FUSION GENE AND THE CLINICOPATHOLOGICAL CHARACTERISTIC IN NON SMALL CELL LUNG CANCER

Thị Thùy Linh Dương 1,, Hoàn Lê1
1 Hanoi medical university

Main Article Content

Abstract

Moleculer target therapy with high specificity and little adverse reactions has become an important therapy for lung cancer. The identification of  EML4-ALK fusion gene in NSCLC represents a new molecular target. Many previous study demonstrated the correlation between the EML4-ALK fusion gene and the clinicopathological characteristic in NSCLC. Objectives: Identifying EML4-ALK fusion gene in NSCLC by Next Generation  Sequencing method and the correlation between the EML4-ALK fusion gene and the clinicopathological characteristic in NSCLC. Subjects and Methods:  A Cross – sectional descriptive study was conducted on 101 NSCLC patients, Next Generation Sequecing medthod were used to identify EML4-ALK Fusion gene. Results: 11/101(10.8%) patients have EML4-ALK fusion gene and EML4-ALK Fusion gene was correlated with age, smoking status and histology, but no significant association was observed betwen EML4-ALK fusion gene and gender.

Article Details

Keywords

Non small cell lung cancer, EML4-ALK fusion gene

References

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