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Date Published: 07/03/2023
Abstract Views: 366
Views PDF: 171
DOI: https://doi.org/10.51298/vmj.v523i2.4505
Issue
Vol. 523 No. 2 (2023)
Section
Các bài báo
How to Cite
Hoàng, T. Đạt, Đỗ, N. S. ., Bùi, T. H. G., & Nguyễn, V. C. (2023). RESULTS OF COUPLED PLASMA FILTRATION AND ADSORPTION (CPFA) IN SUPPORTIVE TREATMENT FOR THE SEPTIC SHOCK PATIENTS. Vietnam Medical Journal, 523(2). https://doi.org/10.51298/vmj.v523i2.4505

RESULTS OF COUPLED PLASMA FILTRATION AND ADSORPTION (CPFA) IN SUPPORTIVE TREATMENT FOR THE SEPTIC SHOCK PATIENTS

Tiến Đạt Hoàng1, Ngọc Sơn Đỗ2,3,, Thị Hương Giang Bùi1,2, Văn Chi Nguyễn2
1 Hanoi medical university
2 Bach Mai hospital
3 VNU - School of Medicine and Pharmacy

Main Article Content

Abstract

Objectives: To describe the improvement of clinical and laboratory parameters when Coupled Plasma Filtration and Adsorption (CPFA) was applied on the septic shock patients. Method: A prospective interventional open study, on 30 patients with septic shock who received CPFA admitted to the Center for Critical Care Medicine from February 2022 to August 2022. All patients were initially treated according to the guidelines of the Surviving Sepsis Campaign 2016. Results: CPFA treatment was associated with a significant of improvement in heart rate (111 vs 99.07, p=0.007), increase of mean arterial pressure (77.43 vs 86.57, p <0.001), reduction of inotropic requirement (0.25 vs 0.05, p<0.001), decrease of SOFA score (9.8 vs 6.9, p<0.001) and decrease of IL-6 level (563.72 vs 359.63, p<0.001), comparing data between pre- and post- CPFA treatment. Hospital mortality was 36.67% and mortality rate of 43.33% at 28 days. Conclusions: Treatment with CPFA improves hemodynamic parameters in septic shock patients and ameliorating organ failure.

Article Details

Keywords

CPFA, Coupled plasma filtration adsorption, sepsis, septic shock

References

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