LIÊN QUAN GIỮA NỒNG ĐỘ BILIRUBIN TOÀN PHẦN HUYẾT TƯƠNG VỚI MỨC ĐỘ TỔN THƯƠNG ĐỘNG MẠCH VÀNH TẠI BỆNH VIỆN TRUNG ƯƠNG THÁI NGUYÊN

Abstract

Bilirubin is believed to have protective effects in coronary artery disease. The relationship between the total plasma bilirubin concentration and the degree of coronary artery damage needs to be further investigated. Objective: To determine the relationship between the concentration of total bilirubin in plasma with the level of coronary artery injury assessed by Gensini scale in patients with an indication for coronary angiography at ThaiNguyen National Hospital. Methods: Cross-sectional descriptive study on 84 patients had a coronary scan at ThaiNguyen National Hospital from March 2020 to February 2021. Results: The mean total plasma bilirubin concentration was 12.57±5.39µmol/L. There was no difference in mean bilirubin concentration between the sexes and the age groups (p>0.05). The group with total plasma bilirubin concentration <17.1µmol/l had a narrow coronary heart rate ≥ 50%, which was 88.9% higher than the group with total bilirubin concentration ≥17.1µmol/l, the rate of narrow ≥ 50% is 57.1%. The difference is statistically significant (OR = 0.2; 95% CI: 0.05 - 0.54; p <0.01). The mean total plasma bilirubin concentration decreased with severity of coronary artery damage according to the mild Gensini score of 15.93 ± 5.17; the mean Gensini score was 12.72 ± 5.15; Gensini severity score was 9.51 ± 3.87, with p <0.001. There is a quite strong inverse correlation between the concentration of total bilirubin in plasma with Gensini score assessing the level of coronary damage in patients with coronary artery disease (r = -0.52, p <0.05). Conclusion: Low plasma bilirubin concentration is associated with severe coronary artery damage (≥50% stenosis and Gensini score); There was a fairly strong inverse relationship with the degree of coronary injury calculated on the Gensini score (r = - 0.52, p <0.001).