YẾU TỐ TIÊN LƯỢNG TỪ CÁC BỆNH NHÂN UNG THƯ BIỂU MÔ BUỒNG TRỨNG GIAI ĐOẠN III ĐƯỢC ĐIỀU TRỊ PHẪU THUẬT CÔNG PHÁ U VÀ HOÁ TRỊ BỔ TRỢ TẠI BỆNH VIỆN K

Abstract

Objects: To determine the prognostic factors for survival and optimal debulking surgery on the stage III epithelial ovarian cancer patients. Methods: Patients with epithelial ovarian cancer stage III undergone the primary debulking surgery and the adjuvant chemotherapy regimens paclitaxel plus carboplatin at the K hospital from January 2015 to December 2019. Clinical and subclinical characteristics, treatment-related variables, progression, recurrence, metastasis and mortality were recorded. Results: 105 eligible patients with epithelial ovarian cancer were analyzed with a median follow-up time of 38 months. The results showed that there was a correlation in overall survival compared with FIGO stage, residual disease, CA125 concentration and HE4 concentration with p test ≤ 0.05. The stage, CA125 level, HE4 concentration, LMR index were significant in predicting primary optimal debulking surgery, with the CA125 cut-off level of 1124 UI/mL with 75.8% sensitivity and 61.7% specificity; the cut-off level of HE4 was 701.5 pmol/L with a sensitivity of 66.7% and a specificity of 78.3%. and the cut-off of LMR was 2.79 with a sensitivity of 54.8% and a specificity of 76.5%. Conclusions: Stage, postoperative residual disease, preoperative CA125 and HE4 concentration are significant prognostic factors for survival in patients with stage III EOC with standard treatment. The combination of factors such as stage, preoperative CA125, HE4, LMR levels proved to be a useful tool to predict optimal surgical ability.